Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Fundamental Motor Skills Assessments Predicting Academic Performance: A Systematic Review. [PDF]
Berahimi E +3 more
europepmc +1 more source
The effect of family physical education environment on gross motor skills in preschool children
Zhao Jia +4 more
openalex +2 more sources
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Schinzel-Giedion syndrome: communication, feeding and motor skills in 16 individuals. [PDF]
Morison LD +4 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cultural differences in motor skills and psychometric evaluation of the MABC-2 in Taiwanese school-aged children. [PDF]
Koh CL, Lee TM, Chen KL, Huang CY.
europepmc +1 more source
Performance of Fine Motor Accuracy Skills and Preschool Children's Jawi Writing Skills
Noratthiah Nordin, Halijah Ibrahim
openalex +1 more source
The effects of programmed training on motor skills of the Serbian armed forces members [PDF]
Ivan Petrović +2 more
openalex +1 more source

