Results 231 to 240 of about 797,919 (301)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Can Hobbies Shape Fine Motor Skills Development in First-Year Dental and Oral Health Students? [PDF]

Eur J Dent Educ
Shetty S, Tran C, Sexton C.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of the relationship between the 2D:4D ratio, fine hand motor skills, and anatomy practical examination performance in first-year medical students. [PDF]

BMC Med Educ
Örs A, Atalar H.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Special Issue "Efficiency in Kinesiology: Innovative Approaches in Enhancing Motor Skills for Athletic Performance, 3rd Edition". [PDF]

J Funct Morphol Kinesiol
Sorgente V, Minciacchi D.
europepmc   +1 more source

Cutting It Too Fine? The Factor Structure of Fine Motor Skills From Ages 5 to 10 Years. [PDF]

Child Dev
Suggate SP, Karle V, Stoeger H.
europepmc   +1 more source

Effectiveness of Transcranial Magnetic Stimulation on Upper Limb Fine Motor Skills in Post-stroke Patients: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Al Jaber M, Alsulaim KM, Kouzeiha RA, Alsuhaibani AA, Lasloom RA, Alghamdi Y, Basheikh K, Alasmari S, Saad R, Abdelkhalek H.   +9 more
europepmc   +1 more source