Results 151 to 160 of about 4,187,793 (246)

Novel Proactive Speech-Language Intervention Is More Effective Than Usual Care: Randomized Controlled Trial of Babble Boot Camp for Infants With Classic Galactosemia. [PDF]

J Speech Lang Hear Res
Potter N, Choi M, Schrock C, Heinlen V, Bruce L, Davis J, Scherer N, Eng L, Finestack L, Stoel-Gammon C, VanDam M, Raaz C, Armstrong-Heimsoth A, Kim Y, Peter B.   +14 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Aquatic Exercise as a Complementary Intervention for Cognitive, Behavioral, Motor, and Functional Outcomes in Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, and Down Syndrome: A Narrative Review. [PDF]

J Clin Med
Montalva-Valenzuela F, Guzmán-Muñoz E, Garcia-Carrillo E, Farias-Valenzuela C, González-Aroca J, Concha-Cisternas Y, Molina-Márquez I, Yañez-Sepúlveda R, Castillo-Paredes A.   +8 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Study protocol of a randomized controlled trial for the effectiveness of psychomotor therapy on quality of life and psychomotor skills in depression. [PDF]

BMC Psychiatry
Pouilloux G, Henault M, Vinais T, Bodeau N, Laplace B, Paquet A.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The Impact of Martial Arts-Based Fall Training Programs on Health and Well-Being in Individuals with Disabilities: A Systematic Review. [PDF]

Healthcare (Basel)
Ângelo H, Massart A, Abrantes J, Sarmento H, Campos MJ, Ferreira JP.   +5 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Establishing preliminary normative reference values for oral motor skills in typically developing Egyptian children using oral placement therapy tools. [PDF]

BMC Pediatr
Zaytoun RAE, Abdel Hady AF, Farag ME, Alasheery RA, Gomaa MM, Amin SM.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source