Results 31 to 40 of about 419,249 (262)

Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

BMC Medicine, 2022
Background The progression of motor and non-motor symptoms (NMS) and the sensitivity of each item of the Unified Multiple System Atrophy Rating Scale (UMSARS) to change remain unclear in Chinese patients with early-stage multiple system atrophy (MSA). We
Lingyu Zhang, Yanbing Hou, Bei Cao, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Yongping Chen, Wei Song, Bi Zhao, Huifang Shang   +12 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms

Frontiers in Aging Neuroscience, 2017
Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor
Jesse Mu, Kallol R. Chaudhuri, Concha Bielza, Jesus de Pedro-Cuesta, Pedro Larrañaga, Pablo Martinez-Martin   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The simultaneous presence of demoralization, apathy, and depression has a detrimental impact on both cognitive function and motor symptoms in Parkinson’s disease patients

Frontiers in Psychiatry
ObjectiveParkinson’s disease (PD) is marked not only by motor symptoms but also by neuropsychiatric manifestations, including demoralization, apathy, and depression.
Xiaobo Zhu, Xiaobo Zhu, Jing Gan, Na Wu, Yu Zhang, Zhenguo Liu   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Non-motor symptoms in Parkinson's disease [PDF]

Arquivos de Neuro-Psiquiatria, 2013
he classic features of the clinical picture in Parkinson’s disease (PD) are the motor disorders: akinesia, rigidity, tremor and postural instability. However, non-motor symptoms (NMS) are frequently present. Therefore, patients with PD can present, besides the typical parkinsonian motor syndrome, a wide arrow of NMS, mainly neuropsychiatric ...
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Remote Assessment of Parkinson’s Disease Patients Amidst the COVID-19 Lockdown in Mexico

Brain Sciences, 2023
The COVID-19 pandemic introduced unprecedented challenges in managing patients with Parkinson’s disease (PD) due to disruptions in healthcare services and the need for social distancing. Understanding the effects of COVID-19 on PD symptoms is crucial for
Rodrigo León-García, Emmanuel Ortega-Robles, Oscar Arias-Carrión   +2 more
doaj   +1 more source

Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish

International Journal of Molecular Sciences, 2023
DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early onset familial Parkinson’s disease and increased astrocytic DJ-1 levels are found in pathologic tissues from idiopathic Parkinson’s disease. We have previously established a
Lakshmi Chavali, Ingeborg Yddal, Ersilia Bifulco, Simen Mannsåker, Dagne Røise, Jack Law, Ann-Kristin Frøyset, Sushma Grellscheid, Kari Fladmark   +8 more
openaire   +4 more sources