Results 51 to 60 of about 499,917 (341)

Determination of Combustion Process Model Parameters in Diesel Engine with Variable Compression Ratio

Journal of Combustion, 2018
Compression ratio has very important influence on fuel economy, emission, and other performances of internal combustion engines. Application of variable compression ratio in diesel engines has a number of benefits, such as limiting maximal in cylinder ...
Saša Milojević, Radivoje Pešić
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Methodology of Multiple-Criteria Decision Making for Selecting a Refrigerant to Be Used in Commercial Refrigeration Equipment

Energies
This paper presents the application of the multiple-criteria decision-making (SAW) method for selecting the optimum refrigerant for the refrigeration systems of commercial cooling equipment used in gastronomy furniture, which is paramount in storing food
Tomasz Bernat, Krzysztof Bieńczak
doaj   +1 more source

Quality Tests of Hybrid Joint–Clinching and Adhesive—Case Study

Applied Sciences, 2022
Inseparable joints are widely used in machine and vehicle construction. Hybrid joints include bonding with sheet metal clinching. This combination reduces costs as well as the time of production compared to welded joints.
Jakub Kowalczyk, Waldemar Matysiak, Wojciech Sawczuk, Daniel Wieczorek, Kamil Sędłak, Michał Nowak   +5 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

R455A Refrigerant as a Prospective Working Fluid in Refrigeration Systems for Gastronomy Furnishings

Energies
The general development of technology and universal access means that gastronomy furnishings can be found in every corner of the world. Therefore, it is important to develop these devices and the machines that constitute them.
Tomasz Bernat, Krzysztof Bieńczak
doaj   +1 more source

Numerical Investigation of Injection Timing Influence on Fuel Slip and Influence of Compression Ratio on Knock Occurrence in Conventional Dual Fuel Engine

Journal of Sustainable Development of Energy, Water and Environment Systems, 2017
Compressed natural gas can be used in diesel engine with great benefits, but because of its low reactivity it is usually used in a so called dual fuel combustion process.
Mario Sremec, Ivan Taritaš, Momir Sjerić, Darko Kozarac   +3 more
doaj   +1 more source

Defectoscopic Susceptibility of Machine Elements

Communications, 2005
In the paper defectoscopic susceptibility of machine elements is analyzed. At first, an objective notion is defined and presented in a practical situation.
Marian Josko
doaj   +1 more source