Results 61 to 70 of about 3,528,498 (350)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Raising sector skills levels : how responsive is local training supply? [PDF]

, 2005
This UK study examines the extent and nature of any mismatches between the training requirements of employers and the local provision of vocational education and training (VET).
Mason, Geoff, Osborne, Matt, Rincon-Aznar, Ana   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Prakiraan Kebutuhan Energi Untuk Kendaraan Bermotor Di Perkotaan: Aspek Pemodelan [PDF]

, 2012
The transportation sector is an important sector to support the national development. As most of the energy demand in the transportation sector is used for motor vehicles in the road transportation, estimating the energy demand for motor vehicles is an ...
Sugiyono, A. (Agus)
core  

Design and implementation of hybrid vehicle using control of DC electric motor [PDF]

, 2019
The electric motors and its control technology are key components of hybrid electric vehicles (HEVs). Control of the electric motor is a fundamental issue for traction application in electric vehicles and HEVs. This paper presents the design, development
Chaudary, Muhammad Akmal, Hussain, Muhammad Majid, Mustafa, Al Rashid, Razaq, Abdul   +3 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Defectoscopic Susceptibility of Machine Elements

Communications, 2005
In the paper defectoscopic susceptibility of machine elements is analyzed. At first, an objective notion is defined and presented in a practical situation.
Marian Josko
doaj   +1 more source

Research on Startup Process for Sensorless Control of PMSMs Based on I-F Method Combined With an Adaptive Compensator

IEEE Access, 2020
Speed control of permanent magnet synchronous motors (PMSMs) without position sensors is preferable in some applications due to cost and mounting space concerns.
Jilei Xing, Zhidong Qin, Cheng Lin, Xiongwei Jiang   +3 more
doaj   +1 more source

Ride Comfort Optimization of In-Wheel-Motor Electric Vehicles with In-Wheel Vibration Absorbers

, 2017
This paper presents an in-wheel vibration absorber for in-wheel-motor electric vehicles (IWM EVs), and a corresponding control strategy to improve vehicle ride comfort.
Li Mingchun, Fei Gu, Yuanzhi Zhang
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source