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Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey

Cerebral Circulation - Cognition and Behavior, 2022
Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR.
Justina L Groeger, Emmeline Ayers, Nir Barzilai, Olivier Beauchet, Michele Callisaya, Maral R. Torossian, Carol Derby, Takehiko Doi, Richard B. Lipton, Sofiya Milman, Sho Nakakubo, Hiroyuki Shimada, Velandai Srikanth, Cuiling Wang, Joe Verghese   +14 more
doaj   +1 more source

38 Plasma proteomic signature of motoric cognitive risk syndrome

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Motoric cognitive risk (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive complaints. In the Atherosclerosis Risk in Communities (ARIC) study, we aim to (1) identify plasma proteins and protein modules ...
Gabriela T. Gomez, Sanish Sathyan, Jingsha Chen, Myriam Fornage, Pascal Schlosser, Zhongsheng Peng, Jenifer Cordon, Priya Palta, Kevin J. Sullivan, Adrienne Tin, B. Gwen Windham, Rebecca F. Gottesman, Josef Coresh, Nir Barzilai, Sofiya Milman, Joe Verghese, Keenan A. Walker   +16 more
doaj   +1 more source

Motoric Cognitive Risk Syndrome: Symptoms, Pathology, Diagnosis, and Recovery

Frontiers in Aging Neuroscience, 2022
The motoric cognitive risk (MCR) syndrome is a pre-dementia condition, marked by the enhanced risk for Alzheimer's disease (AD) and vascular dementia, together with falls, disability, and abnormal movements.
Ke Xiang, Yin Liu, Li Sun
doaj   +1 more source

Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations [PDF]

Annals of Geriatric Medicine and Research, 2020
Changes in gait, especially decreased gait velocity, may be a harbinger of cognitive decline in aging. Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome combining slow gait and cognitive complaints, is a powerful clinical tool used to ...
Zeev Meiner, Emmeline Ayers, Joe Verghese   +2 more
doaj   +1 more source

A Scoping Review to Map Evidence on Motoric Cognitive Risk Syndrome in Older Adults

, 2022
Considering the aging of the world population, there is an expectation of an increase in cases of dementia (WHO, 2012), which can negatively impact the living conditions of older adults and lead to costs related to healthcare.
Gabriela Cipolli, Meire Cachioni, Vanessa Alonso   +2 more
core   +1 more source

Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study. [PDF]

J Gerontol A Biol Sci Med Sci
Contains fulltext : 319820.pdf (Publisher’s version ) (Open Access)BACKGROUND: To investigate whether differences between motoric cognitive risk syndrome (MCRS) and mild cognitive impairment (MCI) are of vascular origin, we compared the
Menart AC, Yaqub A, Dommershuijsen L, Ikram MK, Wolters FJ, Ikram MA.   +5 more
europepmc   +3 more sources

Another Perspective on Huntington’s Disease: Disease Burden in Family Members and Pre-Manifest HD When Compared to Genotype-Negative Participants from ENROLL-HD

Brain Sciences, 2021
Background: In addition to the effects on patients suffering from motor-manifest Huntington’s disease (HD), this fatal disease is devasting to people who are at risk, premanifest mutation-carriers, and especially to whole families. There is a huge burden
Jannis Achenbach, Carsten Saft
doaj   +1 more source

Serum cystatin C: a potential risk factor for motoric cognitive risk syndrome

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate whether serum cystatin C (Cys C) is a potential risk factor for motoric cognitive risk syndrome (MCR) in Chinese elderly. Methods A total of 1592 elderly people were included in the subcohort from Rugao Longevity and Aging Study (
LIU Yan⁃li, ZHAO Rui⁃xue, LI Xiao⁃dong, WANG Xiao⁃feng, JIANG Xiao⁃yan, LI Shu⁃juan   +5 more
doaj   +1 more source

The relationship between spatiotemporal gait parameters and cognitive function in healthy adults: protocol for a cross-sectional study

Pilot and Feasibility Studies, 2022
Background Motor dysfunctions, such as slower walking speed, precede the occurrence of dementia and mild cognitive impairment, suggesting that walking parameters are effective biomarkers for detecting early sub-clinical cognitive risk.
Tatsuya Fukuoka, Shun Irie, Yoshiteru Watanabe, Toshiki Kutsuna, Akiko Abe   +4 more
doaj   +1 more source

Motoric cognitive risk: epidemiology of a walking speed-based syndrome to predict dementia [PDF]

, 2023
Dementia is a huge global health challenge without a cure. Identifying the early stages enables the implementation of risk-modifying interventions when they may be most effective.
Mullin, Donncha Sean
core   +1 more source