Results 1 to 10 of about 50,365 (196)

Phenotypic and genotypic characterization of colistin-resistant Escherichia Coli with mcr-4, mcr-5, mcr-6, and mcr-9 genes from broiler chicken and farm environment

BMC Microbiology, 2023
Background Colistin is an antibiotic used as a last-resort to treat multidrug-resistant Gram-negative bacterial infections. Colistin had been used for a long time in veterinary medicine for disease control and as a growth promoter in food-producing ...
Mulu Lemlem, Erkihun Aklilu, Maizan Mohamed, Nor Fadhilah Kamaruzzaman, Zunita Zakaria, Azian Harun, Susmita Seenu Devan, Intan Noor Aina Kamaruzaman, Mohd Farhan Hanif Reduan, Muthupandian Saravanan   +9 more
doaj   +4 more sources

Deciphering MCR-2 Colistin Resistance [PDF]

MBio, 2017
ABSTRACT Antibiotic resistance is a prevalent problem in public health worldwide. In general, the carbapenem β-lactam antibiotics are considered a final resort against lethal infections by multidrug-resistant bacteria. Colistin is a cationic polypeptide antibiotic and acts as the last line of defense for treatment of carbapenem ...
Xing-Ping Li, Youjun Feng, Yongchang Xu   +2 more
exaly   +5 more sources

Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes [PDF]

Eurosurveillance, 2018
Background and aim Plasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes (mcr-1 to mcr-5, and variants) in Enterobacteriaceae was developed for ...
Rebelo, Ana Rita; id_orcid 0000-0002-9338-9697, Bortolaia, Valeria; id_orcid 0000-0001-6559-7344, Kjeldgaard, Jette S.; id_orcid 0000-0003-1925-9170, Karlsmose Pedersen, Susanne ; id_orcid 0000-0001-7539-8859, Leekitcharoenphon, Pimlapas; id_orcid 0000-0002-5674-0142, Hansen, Inge M., Guerra, Beatriz, Malorny, Burkhard, Borowiak, Maria, Hammerl, Jens Andre, Battisti, Antonio, Franco, Alessia, Alba, Patricia, Perrin-Guyomard, Agnes, Granier, Sophie A., de Frutos, Cristina, Escobar, Malhotra-Kumar, Surbhi, Villa, Laura, Carattoli, Alessandra, Hendriksen, Rene S.; id_orcid 0000-0003-2934-8214   +20 more
core   +9 more sources

Culture-Independent Quantitative PCR Detected Mobilized Colistin Resistance Genes (mcr-1, mcr-2, mcr-3, mcr-4, and mcr-5) in Chicken Gut Contents in Bangladesh [PDF]

Sci
Inappropriate antimicrobial use in food animal farming propels antimicrobial resistance (AMR) that affects all health domains. Colistin is a ‘Reserve’ antibiotic for human treatment to be conserved for multidrug-resistant pathogens; however, it is being used as an animal growth promoter in many developing countries.
Mamun Al Asad, Md Sarower Hossen Shuvo, Shomaia Yasmin Mitu, null Sumia, Md Asief Hossain Zihadi, Ayasha Siddique Shanta, Nahidul Islam, Shamsun Nahar, Brian Godman, Salequl Islam   +9 more
core   +8 more sources

Klebsiella pneumoniae Complex Harboring mcr-1, mcr-7, and mcr-8 Isolates from Slaughtered Pigs in Thailand [PDF]

Microorganisms, 2021
Dissemination of the mobile colistin resistance gene mcr in Enterobacterales among humans, animals, and the environment is a public health issue. We characterized mcr genes in the Klebsiella pneumoniae complex (KpnC) isolated from slaughtered pigs in Thailand. The 280 KpnCs consisted of K.
Peechanika Chopjitt, Parichart Boueroy, Yukihiro Akeda   +2 more
exaly   +4 more sources

Identification of novel mobile colistin resistance gene mcr-10

Emerging Microbes and Infections, 2020
Mobile colistin resistance (mcr) genes represent an emerging challenge. Here we describe a novel mcr gene, mcr-10, on an IncFIA plasmid of an Enterobacter roggenkampii clinical strain.
Yu Feng, Yu Feng, Mei Kang
exaly   +3 more sources

Genomic Characterization of Prevalent mcr-1, mcr-4, and mcr-5 Escherichia coli Within Swine Enteric Colibacillosis in Spain [PDF]

Frontiers in Microbiology, 2019
Antimicrobial agents are crucial for the treatment of many bacterial diseases in pigs, however, the massive use of critically important antibiotics such as colistin, fluoroquinolones and 3rd–4th-generation cephalosporins often selects for co-resistance ...
Isidro García-Meniño, Dafne Díaz-Jiménez, Vanesa García, María de Toro, Saskia C. Flament-Simon, Jorge Blanco, Azucena Mora   +6 more
doaj   +4 more sources

Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs

BMC Research Notes, 2018
Objective Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3,
Jilei Zhang, Li Chen, Jiawei Wang, Patrick Butaye, Ke Huang, Haixiang Qiu, Xiaomei Zhang, Weijuan Gong, Chengming Wang   +8 more
doaj   +2 more sources

Acquired mutations in transcriptional regulator hns and lipopolysaccharide biosynthesis and modification genes impact colistin resistance and fitness of mcr-carrying E. coli [PDF]

Antimicrobial Agents and Chemotherapy
Gram-negative bacteria can develop resistance to the last-resort antimicrobial colistin through the acquisition of mobile colistin resistance (mcr) genes or chromosomal mutations.
Anna Schumann, Ian P. O’Keefe, Robert K. Ernst, Martin Wiedmann   +3 more
doaj   +2 more sources

Transforming Lives: The First 18 Months of the MCR Pathways Mentoring Programme

, 2014
The programme is school-based and aimed at young people who are ‘looked after’ by the local authority or have previously been looked after. The MCR Pathways Mentoring Programme involves four partners: the MCR Charitable Foundation; Glasgow City Council ...
Siebelt, L., Mitchell, I., Fassetta, G.
core   +7 more sources