Results 31 to 40 of about 50,365 (196)

MCR Synthesis of Praziquantel Derivatives [PDF]

Chemical Biology & Drug Design, 2012
Schistosomiasis, a high volume neglected tropical disease affecting more than 200 million people worldwide, can only be effectively treated by the tetrahydroisoquinoline drug praziquantel (PZQ). Herein, we describe an efficient approach to access PZQ derivatives by the Ugi 4‐component reaction followed by the Pictet–Spengler reaction in a two‐step, one‐
Liu, Haixia, William, Samia, Herdtweck, Eberhardt, Botros, Sanaa, Domling, Alexander   +4 more
openaire   +2 more sources

Genomic Evidence of mcr-1.26 IncX4 Plasmid Transmission between Poultry and Humans

Microbiology Spectrum, 2023
Colistin is still commonly used and misused in animal husbandry driving the evolution and dissemination of transmissible plasmid-mediated colistin resistance (mcr).
Ulrike Binsker, Kathrin Oelgeschläger, Bernd Neumann, Guido Werner, Annemarie Käsbohrer, Jens A. Hammerl   +5 more
doaj   +1 more source

Colistin-resistant Escherichia coli with mcr genes in the livestock of rural small-scale farms in Ecuador

BMC Research Notes, 2019
Objective Emergence and dissemination of colistin-resistant (Co-R) bacteria harboring mobile colistin resistance genes pose a threat for treatment of infections caused by multi-drug resistant bacteria.
Yoshimasa Yamamoto, Manuel Calvopina, Ricardo Izurieta, Irina Villacres, Ryuji Kawahara, Masahiro Sasaki, Mayumi Yamamoto   +6 more
doaj   +1 more source

Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

Journal of Antimicrobial Chemotherapy, 2020
Abstract The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family, which is essential for facilitating ...
Zhuoren, Ling, Wenjuan, Yin, Zhangqi, Shen, Yang, Wang, Jianzhong, Shen, Timothy R, Walsh   +5 more
openaire   +2 more sources

MCR-1-dependent lipid remodelling compromises the viability of Gram-negative bacteria

, 2022
The global dissemination of the mobilized colistin resistance gene, mcr-1, threatens human health. Recent studies by our group and others have shown that the withdrawal of colistin as a feed additive dramatically reduced the prevalence of mcr-1. Although
Fan Bai (303042), Siyuan Feng (5998040), Yaxin Li (312731), Daixi Lin (11816534), Yohei Doi (188766), Wanfei Liang (8610954), Lan-Lan Zhong (9702537), Dianrong Zhou (11816537), Li-Na Qin (6286202), Jiachen Li (669381), Hui Zhao (7395), Yong Chen (109188), Min Dai (219435), Huihui Du (5044175), Guo-bao Tian (8610972), Lujie Liang (8610960)   +15 more
core   +1 more source

Whole-Genome Sequencing of Clinically Isolated Carbapenem-Resistant Enterobacterales Harboring mcr Genes in Thailand, 2016–2019

Frontiers in Microbiology, 2021
Mobile colistin-resistant genes (mcr) have become an increasing public health concern. Since the first report of mcr-1 in Thailand in 2016, perspective surveillance was conducted to explore the genomic characteristics of clinical carbapenem-resistant ...
Wantana Paveenkittiporn, Watcharaporn Kamjumphol, Ratchadaporn Ungcharoen, Anusak Kerdsin   +3 more
doaj   +1 more source

A Novel MCR of Isocyanates, Aldehydes, and Dienophiles [PDF]

Organic Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Dirk, Strübing, Helfried, Neumann, Sandra, Hübner, Stefan, Klaus, Matthias, Beller   +4 more
openaire   +2 more sources

Horizontal transfer of a plasmid possessing mcr-1 marked with a single nucleotide mutation between Escherichia coli isolates from community residents

BMC Research Notes, 2022
Objectives The widespread dissemination of phenotypic colistin-resistant (COR) bacteria in the community threatens public health. The horizontal gene transfer of the mobile colistin resistance gene via plasmids is thought to be one of the main mechanisms
Yoshimasa Yamamoto, Ayano Higashi, Kanoko Ikawa, Hoa Thi Thanh Hoang, Takahiro Yamaguchi, Ryuji Kawahara, Hideki Noguchi, Thang Nam Nguyen, Diep Thi Khong, Hoa Thi Tran   +9 more
doaj   +1 more source

Transmission of Similar Mcr-1 Carrying Plasmids among Different Escherichia coli Lineages Isolated from Livestock and the Farmer

Antibiotics, 2021
Colistin use has mostly been stopped in human medicine, due to its toxicity. However, nowadays, it still is used as a last-resort antibiotic to treat hospital infections caused by multi-drug resistant Enterobacteriaceae.
Joaquim Viñes, Anna Cuscó, Sebastian Napp, Julio Alvarez, Jose Luis Saez-Llorente, Montserrat Rosàs-Rodoreda, Olga Francino, Lourdes Migura-Garcia   +7 more
doaj   +1 more source

Colistin Resistance: Role of swine as reservoir of genes mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 in intensive production systems in Brazil

, 2021
A distribuição global de genes de resistência à colistina mediada por plasmídeos, como mcr-1, mcr-2, mcr-3, mcr-4 e mcr-5 representa uma preocupação para a saúde pública, uma vez que a colistina é utilizada como a última linha de defesa para o tratamento
Moreira, Jessica
core   +1 more source