Results 101 to 110 of about 4,518,026 (355)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

Scientific Reports, 2017
The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations.
Aimilios Kaklamanos, Jan Rozman, Manolis Roulis, Niki Karagianni, Maria Armaka, Moya Wu, Laura Brachthäuser, Julia Calzada-Wack, Marion Horsch, Johannes Beckers, Birgit Rathkolb, Thure Adler, Frauke Neff, Eckhard Wolf, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, George Kollias   +17 more
doaj   +1 more source

Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance [PDF]

, 2017
Stephan P. Rosshart, Brian G. Vassallo, Davide Angeletti, Diane S. Hutchinson, Andrew P. Morgan, Kazuyo Takeda, Heather D. Hickman, John A. McCulloch, Jonathan H. Badger, Nadim J. Ajami, Giorgio Trinchieri, Fernando Pardo‐Manuel de Villena, Jonathan W. Yewdell, Barbara Rehermann   +13 more
openalex   +1 more source

Joseph the MoUSE — Mouse Ultrasonic Sound Explorer

SoftwareX
Joseph the MoUSE — Mouse Ultrasonic Sound Explorer (MoUSE) software aims to address the issue of manual analysis of recordings from experiments on rodents by introducing automatic techniques for ultrasonic vocalization (USV) detection. It combines deep learning (DL) methods with classical pattern recognition and computer graphics algorithms.
Adam Kania, Weronika Ormaniec, Dmytro Zhylko, Leszek Grzanka, Diana Piotrowska, Andrzej Siódmok   +5 more
openaire   +4 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Both p16 ^Ink4a and the p19 ^Arf -p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse [PDF]

, 2006
Nabeel Bardeesy, Andrew J. Aguirre, Gerald C. Chu, Kuang‐Hung Cheng, Lyle V. Lopez, Aram F. Hezel, Bin Feng, Cameron Brennan, Ralph Weissleder, Umar Mahmood, Douglas Hanahan, Mark Redston, Lynda Chin, Ronald A. DePinho   +13 more
openalex   +1 more source

Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension [PDF]

, 2023
Monica M. Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola   +12 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

System parameters for erythropoiesis control model: Comparison of normal values in human and mouse model [PDF]

The computer model for erythropoietic control was adapted to the mouse system by altering system parameters originally given for the human to those which more realistically represent the mouse.

core   +1 more source

ANTI-MOSQUITO BEHAVIOR OF ADULT AND JUVENILE WHITE-FOOTED MICE (PEROMYSCUS LEUCOPUS) (TREEHOLE MOSQUITO, AEDES TRISERIATUS, EPIDEMIOLOGY) [PDF]

, 1986
Rodents seldom are identified as hosts for mosquitoes, based on serological analysis of bloodmeals. However, due to limited survey and lack of sensitivity in most bloodmeal analyses, host species can be misrepresented or undetected. Knowledge of behavior
ISAACS, CONNIE
core   +1 more source