Results 161 to 170 of about 4,061,393 (306)

Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V_H1-2-rearranging mouse models. [PDF]

Proc Natl Acad Sci U S A
Batra H, Luo S, Saunders KO, Higgins JS, Jian F, Zhang J, Kibria MG, Jonaid GM, Zhou QJ, Eaton A, Cronin K, Mallory ML, Mattocks M, Edwards RJ, Parks R, Lee EM, Ye AY, Williams AC, Jung G, Mansouri K, Alam SM, Montefiori DC, Tian M, Baric RS, Cao Y, Haynes BF, Chen B, Alt FW.   +27 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ^{L301R-V303R/L301R-V303R} Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain. [PDF]

Biomolecules
Jacobs B, Ivanov D, Barraza I, Faulk C, Booth CJ, Mattos-Canedo R, Tian L, DePietro K, Uzun A, Roos WP, Sanders LH, Sobol RW.   +11 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Correspondence of large-scale functional brain network decline across aging mice and humans. [PDF]

Proc Natl Acad Sci U S A
Winter-Nelson E, Bergmann E, Chan MY, Vill G, Han L, Zhang Z, Kavushansky A, Dolgopyat I, Asleh J, Whitesell JD, Kahn I, Wig GS.   +11 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Nintedanib Lacks Efficacy in a Spirometry-Confirmed and Bleomycin-Induced Mouse Model of Idiopathic Pulmonary Fibrosis. [PDF]

Basic Clin Pharmacol Toxicol
Bousamaki J, Maciag G, Petersen AG, Korntner SH, Jansen SM, Pors SE, Mamsen LS, Rasmussen SA, Salinas CG, Kruse LH, Feigh M, Simonsen U, Hansen HH.   +12 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Minigenes for heterologous expression of human and mouse cationic trypsinogen. [PDF]

PLoS One
Berke G, Sahin-Tóth M.
europepmc   +1 more source