Results 171 to 180 of about 3,713,315 (228)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Prion replication in organotypic brain slice cultures is distinct from in vivo inoculation and is species dependent. [PDF]

Acta Neuropathol Commun
Slota JA, Lamoureux L, Myskiw J, Frost KL, Medina SJ, Kielich DMS, Leonhardt M, Thapar G, Bailey-Elkin BA, Booth SA.   +9 more
europepmc   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Vasomotion loss precedes impaired cerebrovascular reactivity and microbleeds in cerebral amyloid angiopathy. [PDF]

Brain Commun
Kozberg MG, Munting LP, Hanlin LH, Auger CA, van den Berg ML, Denis de Senneville B, Hirschler L, Warnking JM, Barbier EL, Farrar CT, Greenberg SM, Bacskai BJ, van Veluw SJ.   +12 more
europepmc   +1 more source

A Better Mouse Trap [PDF]

, 1949
Bradway, John S.
core   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Implementation of needle‐tracking technology for real‐time transrectal ultrasound‐guided interstitial gynecological HDR brachytherapy: A feasibility study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To investigate the feasibility of adapting a commercial prostate biopsy system for transrectal ultrasound (TRUS)‐guided hybrid gynecological (GYN) high‐dose‐rate (HDR) brachytherapy (BT). Leveraging 3D‐TRUS and MR image fusion, the prototype system aims to improve real‐time needle placement accuracy.
Lindsey H. Bloom, Diandra Ayala‐Peacock, Rajesh Venkataraman, Brett Eckroate, Ryan Sanford, Junzo Chino, Yongbok Kim, Julie Raffi, Oana Craciunescu   +8 more
wiley   +1 more source

Heterogeneity in pericyte inflammatory responses across age and species highlight the importance of human cell models. [PDF]

Mol Brain
Stevenson TJ, Lee K, Li S, Montgomery JM, Lee KY, Dragunow M.   +5 more
europepmc   +1 more source

Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge, Reiner Geyer, Rémy Kinj, Luis Schiappacasse, Wendy Jeanneret‐Sozzi, Jean Bourhis, Fernanda Herrera, François Bochud, Claude Bailat, Raphaël Moeckli   +9 more
wiley   +1 more source

Ectonucleotidases and purinergic receptors in mouse prostate gland. [PDF]

Am J Clin Exp Urol
Yu J, Sharkey C, Olumi AF, Wang Z.
europepmc   +1 more source