Developing reference plans for evaluating global clinical trials credentialing and PSQA systems
Abstract Purpose To develop a practical framework for creating a diverse set of validated reference plans (varying in complexity) and implement a workflow to introduce beam modeling, calibration, and delivery errors into the reference cohort to test and compare various dosimetry audit methodologies.
Fre'Etta M. D. Brooks+13 more
wiley +1 more source
Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and humans. [PDF]
Ebelt ND+3 more
europepmc +1 more source
Claustrum Volume Is Reduced in Multiple Sclerosis and Predicts Disability
ABSTRACT Objective The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS). Methods This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific ...
Nicole Shelley+5 more
wiley +1 more source
A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen+8 more
wiley +1 more source
Gut microbiota deficiency reduces neutrophil activation and is protective after ischemic stroke. [PDF]
Tuz AA+27 more
europepmc +1 more source
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu+12 more
wiley +1 more source
Flow Cytometric Analysis and Sorting of Murine Enteric Nervous System Cells: An Optimized Protocol. [PDF]
Karkala F+6 more
europepmc +1 more source
Leveraging microtopography to pattern multi-oriented muscle actuators.
Rossy T+8 more
europepmc +1 more source
Editorial: Women in science: musculoskeletal pain. [PDF]
Shannonhouse J, Kim YS.
europepmc +1 more source