Results 191 to 200 of about 3,713,315 (228)

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival. [PDF]

Elife
Goswami MT, Weh E, Subramanya S, Weh KM, Durumutla HB, Hager H, Miller N, Chaudhury S, Andren A, Sajjakulnukit P, Zhang L, Besirli C, Lyssiotis CA, Wubben TJ.   +13 more
europepmc   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Involvement of membrane palmitoylated protein 6 (MPP6) in synapses of mouse cerebrum. [PDF]

Histochem Cell Biol
Saitoh Y, Motofuji S, Kamijo A, Suzuki T, Yoshizawa T, Sakamoto T, Kametani K, Terada N.   +7 more
europepmc   +1 more source

A novel mouse model for X-linked Alport syndrome induced by splicing mutation in the Col4a5 gene. [PDF]

Sci Rep
Ye Z, Lu D, Zhou S, Li G, Long L, Zhang J, Liu M, Gao X.   +7 more
europepmc   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis. [PDF]

PLoS One
Omer N, Wilczynski E, Zlotzover S, Helft C, Blumenfeld-Katzir T, Ben-Eliezer N.   +5 more
europepmc   +1 more source

Chronic wasting disease as a model for human prion therapy. [PDF]

Prion
Bordonaro M.
europepmc   +1 more source

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson's disease models and restores functions in Gaucher's disease models. [PDF]

PLoS One
Okai T, Sato S, Deshpande M, Matsumoto SI, Nakayama M, Yamamoto S, Strack-Logue B, Hioki T, Tanaka M, Proetzel G.   +9 more
europepmc   +1 more source

Neointimal Smooth Muscle Cells in Mouse Vein Grafts are not Recruited from the Adjacent Artery.

J Vasc Res
Österberg K, Håkansson J, Mattsson E.
europepmc   +1 more source