Results 191 to 200 of about 5,417,964 (375)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells

Cell, 2003
Kaoru Mitsui, Yoshimi Tokuzawa, Hiroaki Itoh, K. Segawa, M. Murakami, Kazutoshi Takahashi, Masayoshi Maruyama, M. Maeda, S. Yamanaka   +8 more
semanticscholar   +1 more source

The sex chromosome in the house mouse [PDF]

, 1947
Ronald Aylmer Fisher, Mary F. Lyon, Andrew Owen   +2 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

The Antigenic Composition of Mouse Ascites Tumour Cells Using In Vitro and Gel-diffusion Techniques [PDF]

, 1957
G C Easty, E. J. AMBROSE
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Science, 2016
Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim, A. Frouin, Shaoming Li, Saranya Ramakrishnan, Katherine M. Merry, Qiaoqiao Shi, A. Rosenthal, B. Barres, C. Lemere, D. Selkoe, B. Stevens   +12 more
semanticscholar   +1 more source

Quantification of Oxygenation and Oxygen Consumption Rates in the Mouse Brain Based on Tissue Oxygen Level-Dependent (TOLD) MRI. [PDF]

NMR Biomed
Parajuli RK, Sano H, Ueno M, Gao S, Suzuki S, Sumiyoshi A, Osada K, Obata T, Aoki I, Matsumoto KI.   +9 more
europepmc   +1 more source

THE FINE STRUCTURE OF THE INTERSTITIAL CELL IN THE MOUSE OVARY STUDIED WITH ELECTRON MICROSCOPE

, 1958
TOYOKO MUTA
openalex   +2 more sources

Locus of the Gene ‘Fidget’ in the House Mouse [PDF]

, 1950
Margaret E. Wallace
openalex   +1 more source