Results 201 to 210 of about 4,518,026 (355)

A high-fat diet induces rapid changes in the mouse hypothalamic proteome [PDF]

, 2019
Fiona Hamilton McLean, Fiona Campbell, Rosamund F. Langston, Domenico Sergi, Cibell Resch, Christine Grant, Amanda C. Morris, Claus Mayer, Lynda M. Williams   +8 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

HDAC6 Inhibition Reduces Seeded Tau and α-Synuclein Pathologies in Primary Neuron Cultures and Wild-Type Mice. [PDF]

J Neurosci
Crowe A, Yao Y, Newman M, Hoxha K, Baffic T, Brunden KR.   +5 more
europepmc   +1 more source

Midbrain neurons important for the production of mouse ultrasonic vocalizations are not required for distress calls [PDF]

Patryk Ziobro, Yena Woo, Zichen He, Katherine Tschida   +3 more
openalex   +1 more source

Naturally occurring coumarins inhibit 7,12-dimethylbenz[ a ]anthracene DNA adduct formation in mouse mammary gland [PDF]

, 2005
Misty Prince, Cheryl T. Campbell, Taylor A. Robertson, Amy Wells, Heather E. Kleiner   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional neural stem cells via the SWI/SNF-E2F axis. [PDF]

Sci Adv
Liang Y, Grinchuk OV, Cipta NO, Zeng Y, Chuah YH, Yoon J, Khong ZJ, Chow HY, Ng W, Ong CT, Ling SC, Ng SY, Loh YH, Ong DST.   +13 more
europepmc   +1 more source

A Better Mouse Trap [PDF]

, 1949
Bradway, John S.
core   +1 more source

Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain [PDF]

, 2013
Wim Maes, Tina Verschuere, Anaïs Van Hoylandt, Louis Boon, Stefaan Van Gool   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source