Results 211 to 220 of about 4,061,393 (306)

High-power dual-channel chamber for high-frequency magnetic neuromodulation. [PDF]

J Neural Eng
Tian X, Wang H, Wang B, Zhang J, Yan D, Ingabire J, Coffler S, Duret G, Pham QK, Bao G, Wang J, Veeraraghavan A, Robinson JT, Goetz SM, Peterchev AV.   +14 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy. [PDF]

Exp Hematol Oncol
Xiong S, Zhou R, Wei C, Wang X, Tang Y, Dong L, Yu P, Pei D, Chen Z, Chen SJ, Cheng L.   +10 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing. [PDF]

FASEB J
Lu X, Morisseau C, Jain K, Chen Z, Estes AJ, Zeldin D, Gruzdev A, Ahmed A, Cook H, Hammock BD, Watsky MA.   +10 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Cross-species scRNA-seq finds ideal mouse models for aortic dissection mechanisms. [PDF]

iScience
Cao G, Qiu S, Hu C, Kan Y, Li Z, Li S, Feng Q, Fu W, Wang L.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates. [PDF]

MAbs
Christianson G, Howard ZM, Kenney S, Lowell E, Bethur N, Roopenian D, Gonzalo-Gil E.   +6 more
europepmc   +1 more source