Results 31 to 40 of about 16,048,322 (262)

Preclinical Ultrasound Imaging—A Review of Techniques and Imaging Applications

Frontiers in Physics, 2020
Ultrasound imaging is a well-established clinical imaging technique providing real-time, quantitative anatomical and physiological information in humans.
Carmel M. Moran, Adrian J. W. Thomson
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology [PDF]

, 2017
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping.
Eric Dufour, Dufour, E., Gellerich, Frank, Gainutdinov, T., Wietelmann, Astrid, Holmström, Kira Margareta, German Mouse Clinic Consortium, Gizatullina, Z., Jacobs, Howard T, Rustin, Pierre, Marten Szibor, Kira M. Holmström, Astrid Wietelmann, Gainutdinov, Timur, Nandania, J., Thomas Braun, Heidler, J., Velagapudi, Vidya, Martin Hrabě de Angelis, Szibor, M., Pierre Rustin, de Angelis, Martin Hrabe, de Angelis, M., Braun, Thomas, Yuan Zhuang, Jatin Nandania, Dhandapani, Praveen, Fuchs, H., Velagapudi, V., Wittig, Ilka, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Valérie Gailus-Durner, Gellerich, Frank Norbert, Gailus-Durner, V., Timur Gainutdinov, Dufour, Eric, Helmut Fuchs, Vidya Velagapudi, Zhuang, Y., Wittig, I., Gellerich, F., Holmström, Kira, German Mouse Clinic Consortium, Praveen K. Dhandapani, Szibor, Marten, Jacobs, Howard T., Howard T. Jacobs, Jacobs, H., Zemfira Gizatullina, Frank N. Gellerich, Salwig, Isabelle, Dhandapani, P., Juliana Heidler, Braun, T., Heidler, Juliana, Ilka Wittig, Rustin, P., Zhuang, Yuan, Holmstrom, Kira M., Holmstrom, K., Fuchs, Helmut, Isabelle Salwig, Gizatullina, Zemfira, Dhandapani, Praveen K., Nandania, Jatin, Wietelmann, A., Gellerich, Frank N., Salwig, I.   +68 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Weight loss is a sufficient and economical single outcome measure of murine dextran sulfate sodium colitis

FASEB BioAdvances, 2019
Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming common around the world without a cure. Animal models of colitis have become instrumental in IBD research.
Savini Lanka Britto, Mahesh Krishna, Richard Kellermayer   +2 more
doaj   +1 more source

A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson’s disease [PDF]

, 2015
Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding ...
Geldenhuys, Werner, Pienaar, Ilse, Young, Jesse, Dean E. Dluzen, Werner J. Geldenhuys, Tamara L. Guseman, Ilse S. Pienaar, Jesse W. Young, Dluzen, Dean, Guseman, Tamara   +9 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Nature Communications, 2018
The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory ...
Jan Rozman, Birgit Rathkolb, Manuela A. Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage, Terrence F. Meehan, Jeremy Mason, Hamed Haselimashhadi, IMPC Consortium, Tertius Hough, Ann-Marie Mallon, Sara Wells, Luis Santos, Christopher J. Lelliott, Jacqueline K. White, Tania Sorg, Marie-France Champy, Lynette R. Bower, Corey L. Reynolds, Ann M. Flenniken, Stephen A. Murray, Lauryl M. J. Nutter, Karen L. Svenson, David West, Glauco P. Tocchini-Valentini, Arthur L. Beaudet, Fatima Bosch, Robert B. Braun, Michael S. Dobbie, Xiang Gao, Yann Herault, Ala Moshiri, Bret A. Moore, K. C. Kent Lloyd, Colin McKerlie, Hiroshi Masuya, Nobuhiko Tanaka, Paul Flicek, Helen E. Parkinson, Radislav Sedlacek, Je Kyung Seong, Chi-Kuang Leo Wang, Mark Moore, Steve D. Brown, Matthias H. Tschöp, Wolfgang Wurst, Martin Klingenspor, Eckhard Wolf, Johannes Beckers, Fausto Machicao, Andreas Peter, Harald Staiger, Hans-Ulrich Häring, Harald Grallert, Monica Campillos, Holger Maier, Helmut Fuchs, Valerie Gailus-Durner, Thomas Werner, Martin Hrabe de Angelis   +64 more
doaj   +1 more source