Results 21 to 30 of about 16,048,322 (262)

Construction and characterization of an infectious cDNA clone of coxsackievirus A 10

Virology Journal, 2019
Background Coxsackievirus A10 (CA10) constitutes one of the four major pathogens causing hand, foot and mouth disease in infants. Infectious clones are of great importance for studying viral gene functions and pathogenic mechanism.
Qiliang Liu, Hanliang Dan, Xiaoping Zhao, Huoying Chen, Yongbei Chen, Ning Zhang, Zhijing Mo, Hongbo Liu   +7 more
doaj   +1 more source

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

Journal of Translational Medicine, 2020
Background Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineage hierarchy, and tumor ...
Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone, Xinhui Wang   +14 more
doaj   +1 more source

Endometriosis in the Mouse: Challenges and Progress Toward a ‘Best Fit’ Murine Model

Frontiers in Physiology, 2022
Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation.
Katherine A. Burns, Amelia M. Pearson, Jessica L. Slack, Elaine D. Por, Alicia N. Scribner, Nazmin A. Eti, Richard O. Burney, Richard O. Burney   +7 more
doaj   +1 more source

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Animal Models and Experimental Medicine, 2020
Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new ...
Rui C. Oliveira, Ana Margarida Abrantes, José Guilherme Tralhão, Maria Filomena Botelho   +3 more
doaj   +1 more source

Touchscreen-based cognitive tasks reveal age-related impairment in a primate aging model, the grey mouse lemur (Microcebus murinus) [PDF]

, 2014
Mouse lemurs are suggested to represent promising novel non-human primate models for aging research. However, standardized and cross-taxa cognitive testing methods are still lacking.
Sandra Ammersdörfer (641760), Daniel Schmidtke (417120), Daniel Schmidtke, Marine Joly (162473), Schmidtke, Daniel, Sandra Ammersdörfer, Elke Zimmermann (76427), Ammersdorfer, Sandra, Joly, Marine, Zimmermann, Elke, Elke Zimmermann, Marine Joly   +11 more
core   +2 more sources

Developmental aspect of decidual patterning

Reproductive and Developmental Medicine, 2017
In clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium.
Chan Zhou, Hai-Li Bao, Shuang-Bo Kong, Jin-Hua Lu, Hai-Bin Wang   +4 more
doaj   +1 more source

Loss of Sult1a1 reduces body weight and increases browning of white adipose tissue

Frontiers in Endocrinology
Background and objectiveOverweight and obesity affects millions of individuals worldwide and consequently represents a major public health concern. Individuals living with overweight and obesity have difficulty maintaining a low body weight due to known ...
Margherita Springer, Margherita Springer, Emmanuelle Meugnier, Katharina Schnabl, Katharina Schnabl, Katharina Schnabl, Kevin Sebastiaan Hof, Marie-France Champy, Tania Sorg, Benoit Petit-Demoulière, Natacha Germain, Natacha Germain, Bogdan Galusca, Bogdan Galusca, Bruno Estour, Bruno Estour, Hubert Vidal, Martin Klingenspor, Martin Klingenspor, Martin Klingenspor, Jörg Hager   +20 more
doaj   +1 more source

Physachenolide C induces complete regression of established murine melanoma tumors via apoptosis and cell cycle arrest

Translational Oncology, 2022
Melanoma is an aggressive skin cancer that metastasizes to other organs. While immune checkpoint blockade with anti-PD-1 has transformed the treatment of advanced melanoma, many melanoma patients fail to respond to anti-PD-1 therapy or develop acquired ...
Anngela C. Adams, Anne M. Macy, Paul Kang, Karla F. Castro-Ochoa, E.M. Kithsiri Wijeratne, Ya-Ming Xu, Manping X. Liu, Alexandra Charos, Marcus W. Bosenberg, A.A. Leslie Gunatilaka, Aparna R. Sertil, K. Taraszka Hastings   +11 more
doaj   +1 more source

Dominant effects of the immediate environment on the gut microbiome of mice used in biomedical research

mSystems
Studies using genetically engineered mouse (GEM) models are often performed over extended periods. The microbiomes of GEM colonies are expected to retain some of the microbial features present in the founder mice used to generate each GEM model and to ...
Aaron C. Ericsson, Zachary L. McAdams, Rebecca A. Dorfmeyer, Marcia L. Hart, Armedia O’Neill-Blair, James Amos-Landgraf, Craig L. Franklin   +6 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source