Results 1 to 10 of about 1,682,428 (119)

Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation

Frontiers in Immunology, 2021
Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver. The impairment of T cell response limits the control of chronic hepatotropic viruses.
Kingsley Gideon Kumashie, Marcin Cebula, Claudia Hagedorn, Florian Kreppel, Marina C. Pils, Friedrich Koch-Nolte, Björn Rissiek, Dagmar Wirth, Dagmar Wirth   +8 more
doaj   +1 more source

Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing

Frontiers in Oncology, 2021
Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression.
Chong Liu, Pei Wu, Ailin Zhang, Xiaoyun Mao   +3 more
doaj   +1 more source

Polymerase chain reaction-based assays facilitate the breeding and study of mouse models of Klinefelter syndrome

Asian Journal of Andrology, 2022
Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and the leading genetic cause of nonobstructive azoospermia. The breeding and study of KS mouse models are essential to advancing our knowledge of the underlying pathological ...
Hai-Xia Zhang, Yu-Lin Zhou, Wen-Yan Xu, Xiao-Lu Chen, Jia-Yang Jiang, Xiao-Man Zhou, Zeng-Ge Wang, Rong-Qin Ke, Qi-Wei Guo   +8 more
doaj   +1 more source

Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes

Scientific Reports, 2022
We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes.
Kendall Higgins, Bret A. Moore, Zorana Berberovic, Hibret A. Adissu, Mohammad Eskandarian, Ann M. Flenniken, Andy Shao, Denise M. Imai, Dave Clary, Louise Lanoue, Susan Newbigging, Lauryl M. J. Nutter, David J. Adams, Fatima Bosch, Robert E. Braun, Steve D. M. Brown, Mary E. Dickinson, Michael Dobbie, Paul Flicek, Xiang Gao, Sanjeev Galande, Anne Grobler, Jason D. Heaney, Yann Herault, Martin Hrabe de Angelis, Hsian-Jean Genie Chin, Fabio Mammano, Chuan Qin, Toshihiko Shiroishi, Radislav Sedlacek, J.-K. Seong, Ying Xu, The IMPC Consortium, K. C. Kent Lloyd, Colin McKerlie, Ala Moshiri   +35 more
doaj   +1 more source

Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice

Viruses, 2023
Chikungunya virus (CHIKV) is a mosquito-transmitted pathogen that causes chikungunya disease (CHIK); the disease is characterized by fever, muscle ache, rash, and arthralgia.
Douglas Barker, Xiaobing Han, Eryu Wang, Ashley Dagley, Deborah M. Anderson, Aruni Jha, Scott C. Weaver, Justin Julander, Cory Nykiforuk, Shantha Kodihalli   +9 more
doaj   +1 more source

A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model

Frontiers in Surgery, 2022
ObjectiveTo establish a simple and practical model for super-microsurgery training using the middle caudal arteries of Kunming mice.MethodsA ⊔-shaped incision was made approximately 1 cm from the root of the tail in the mouse, and the skin, together with
Xue-Qiang Wu, Hui-Ren Liu, Zhan-Yong Yu, Yan Wang, Ru-Tao Sun, Li Wang, Yuan Gao   +6 more
doaj   +1 more source

Novel Disturbed‐Flow–Induced Atherosclerosis Mouse Model [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Dunpeng Cai, Ruimei Zhou, Lindsey Saint, Zhenguo Liu, Shi‐You Chen   +4 more
doaj   +2 more sources

Generation of an immunodeficient mouse model of tcirg1-deficient autosomal recessive osteopetrosis

Bone Reports, 2020
Background: Autosomal recessive osteopetrosis is a rare skeletal disorder with increased bone density due to a failure in osteoclast bone resorption. In most cases, the defect is cell-autonomous, and >50% of patients bear mutations in the TCIRG1 gene ...
Eleonora Palagano, Sharon Muggeo, Laura Crisafulli, Irina L. Tourkova, Dario Strina, Stefano Mantero, Elena Fontana, Silvia L. Locatelli, Marta Monari, Emanuela Morenghi, Carmelo Carlo-Stella, John B. Barnett, Harry C. Blair, Paolo Vezzoni, Anna Villa, Cristina Sobacchi, Francesca Ficara   +16 more
doaj   +1 more source

Prevalence of sexual dimorphism in mammalian phenotypic traits

Nature Communications, 2017
Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory ...
Natasha A. Karp, Jeremy Mason, Arthur L. Beaudet, Yoav Benjamini, Lynette Bower, Robert E. Braun, Steve D.M. Brown, Elissa J. Chesler, Mary E. Dickinson, Ann M. Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J. Justice, Natalja Kurbatova, Christopher J. Lelliott, K.C. Kent Lloyd, Ann-Marie Mallon, Judith E. Mank, Hiroshi Masuya, Colin McKerlie, Terrence F. Meehan, Richard F. Mott, Stephen A. Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R. Seavitt, Damian Smedley, Tania Sorg, Anneliese O. Speak, Karen P. Steel, Karen L. Svenson, International Mouse Phenotyping Consortium, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K. White   +43 more
doaj   +1 more source

HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studies

Journal of Translational Medicine, 2023
Background Infection with high-risk human papillomavirus (HPV) strains is one of the risk factors for the development of oral squamous cell carcinoma (OSCC).
Ziva Modic, Maja Cemazar, Bostjan Markelc, Andrej Cör, Gregor Sersa, Simona Kranjc Brezar, Tanja Jesenko   +6 more
doaj   +1 more source