Results 1 to 10 of about 1,617,868 (269)
Frontiers in Immunology, 2021 Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver. The impairment of T cell response limits the control of chronic hepatotropic viruses.
Kingsley Gideon Kumashie +8 more
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Advances in Rodent Models for Breast Cancer Formation, Progression, and Therapeutic Testing
Frontiers in Oncology, 2021 Breast cancer is a highly complicated disease. Advancement in the treatment and prevention of breast cancer lies in elucidation of the mechanism of carcinogenesis and progression.
Chong Liu +3 more
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Mouse models of medulloblastoma [PDF]
Chinese Journal of Cancer, 2011 Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of ...
Wu, Xiaochong +3 more
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Asian Journal of Andrology, 2022 Klinefelter syndrome (KS) is one of the most frequent genetic abnormalities and the leading genetic cause of nonobstructive azoospermia. The breeding and study of KS mouse models are essential to advancing our knowledge of the underlying pathological ...
Hai-Xia Zhang +8 more
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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes
Scientific Reports, 2022 We searched a database of single-gene knockout (KO) mice produced by the International Mouse Phenotyping Consortium (IMPC) to identify candidate ciliopathy genes.
Kendall Higgins +35 more
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Equine Polyclonal Antibodies Prevent Acute Chikungunya Virus Infection in Mice
Viruses, 2023 Chikungunya virus (CHIKV) is a mosquito-transmitted pathogen that causes chikungunya disease (CHIK); the disease is characterized by fever, muscle ache, rash, and arthralgia.
Douglas Barker +9 more
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Platelets, 2020 Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders ...
Bassem M. Mohammed +2 more
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Molecular Psychiatry, 1999 Psychiatric disorders have important genetic contributions, but it has been very difficult to identify the responsible genes using human populations. Recent developments in mouse genomics hold considerable promise of providing important insights into the genetics of these diseases.
V, Brown, D, Smith
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A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model
Frontiers in Surgery, 2022 ObjectiveTo establish a simple and practical model for super-microsurgery training using the middle caudal arteries of Kunming mice.MethodsA ⊔-shaped incision was made approximately 1 cm from the root of the tail in the mouse, and the skin, together with
Xue-Qiang Wu +6 more
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Mouse models of the laminopathies [PDF]
Experimental Cell Research, 2007 The A and B type lamins are nuclear intermediate filament proteins that comprise the bulk of the nuclear lamina, a thin proteinaceous structure underlying the inner nuclear membrane. The A type lamins are encoded by the lamin A gene (LMNA). Mutations in this gene have been linked to at least nine diseases, including the progeroid diseases Hutchinson ...
Colin L, Stewart +3 more
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