Results 81 to 90 of about 1,832,552 (317)
, 2012 Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs.
Miquel Taron +64 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2020 Mouse-tracking model results, filler trials in Experiment 1: Results from ordinal generalised additive mixed model of object towards which the cursor had moved most up to that time bin (referent > neither > distractor).
Martin Corley (351455) +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2018 <p>R code for implementing Cormack-Jolly-Seber capture recapture model for mouse enclosure experiment described in Barrett et al.
M'Gonigle, Leithen K. +1 more
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, 2020 Mouse-tracking model results, Experiment 2: Results from ordinal generalised additive mixed model of object towards which the cursor had moved most up to that time bin (referent > neither > distractor).
Martin Corley (351455) +3 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Cellular, molecular and functional characterisation of YAC transgenic mouse models of Friedreich Ataxia [PDF]
, 2014 Copyright © 2014 Anjomani Virmouni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author ...
Al-Mahdawi, S +17 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
, 2004 Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research
Hedrich, Hans J., Bullock, Gillian R.
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