Results 101 to 110 of about 7,916,685 (373)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Cucumber Mosaic Virus Movement Protein Severs Actin Filaments to Increase the Plasmodesmal Size Exclusion Limit in Tobacco[W][OA]

The Plant Cell, 2010
Viral movement proteins (MPs) enable viral pathogens to pass through cell walls by increasing the size exclusion limit (SEL) of plasmodesmata (PD). Cucumber mosaic virus (CMV) MP was found to bind and sever actin filament (F-actin) in vitro, and such ...
S. Su, Zhao-Hua Liu, Cheng Chen, Yan Zhang, Xu Wang, Lei Zhu, Long Miao, Xue-Chen Wang, M. Yuan   +8 more
semanticscholar   +1 more source

Signaling in plants by intercellular RNA and protein movement [PDF]

Genes & Development, 2002
Plants and animals have had about 1.6 billion years—the time that has passed since they diverged from their last unicellular ancestor—to evolve different mechanisms for solving unique problems of development and intercellular signaling. As an example, plant cells are separated from each other by a substantial extracellular matrix, the cell wall ...
Xuelin Wu, Detlef Weigel, Philip A. Wigge   +2 more
openaire   +3 more sources

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Aitken, Anand, Brachmann, Browne, Carlini, Chan, Charneski, Chu, Chu, Chu, Ciandrini, Dana, Firczuk, Fluitt, Gibson, Gould, Grant, Haar, Haar, Hense, Hershberg, Hu, Ikemura, Ingolia, Ingolia, Jeon, Kemp, Kotula, Kudla, Liti, Liu, Lombardi, McCarthy, Merritt, Mirzaei, Moriya, Mossadegh, Nagata, Neafsey, Outchkourov, Patel, Plant, Powell, Qian, Sala-Newby, Salas-Marco, Shalgi, Sikorski, Sinclair, Slimko, Stadler, Stark, Wolin, Yadava, Zhou, Zouridis   +55 more
core   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses

Frontiers in Plant Science, 2014
Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama, Harumi eShimada-Beltran, Amit eLevy, Judy Y Zheng, Parth A Javia, Sondra Gale Lazarowitz   +5 more
doaj   +1 more source

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

npj Parkinson's Disease, 2023
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be ...
Sara Gomes, Alicia Garrido, Francesca Tonelli, Donina Obiang, Eduardo Tolosa, Maria José Martí, Javier Ruiz-Martínez, Ana Vinagre-Aragón, Haizea Hernandez-Eguiazu, Ioana Croitoru, Vicky L. Marshall, Theresa Koenig, Christoph Hotzy, Frank Hsieh, Marianna Sakalosh, Elizabeth Tengstrand, Shalini Padmanabhan, Kalpana Merchant, Christof Bruecke, Walter Pirker, Alexander Zimprich, Esther Sammler   +21 more
doaj   +1 more source

Cellular Partners of Tobamoviral Movement Proteins

International Journal of Molecular Sciences
The size of viral genomes is limited, thus the majority of encoded proteins possess multiple functions. The main function of tobamoviral movement protein (MP) is to perform plasmodesmata gating and mediate intercellular transport of the viral RNA. MP is a remarkable example of a protein that, in addition to the initially discovered and most obvious ...
Natalia M. Ershova, Kamila A. Kamarova, Ekaterina V. Sheshukova, Tatiana V. Komarova   +3 more
openaire   +2 more sources

The C terminus of the movement protein of Brome mosaic virus controls the requirement for coat protein in cell-to-cell movement and plays a role in long-distance movement

Journal of General Virology, 2004
The 3a movement protein (MP) plays a central role in the movement ofBrome mosaic virus(BMV). To identify the functional regions in BMV MP, 24 alanine-scanning (AS) MP mutants of BMV were constructed. Infectivity of the AS mutants in the host plantChenopodium quinoashowed that the central region of BMV MP is important for viral movement and both termini
Atsushi Takeda, Tetsuro Okuno, Kazuyuki Mise, Masanori Kaido   +3 more
openaire   +3 more sources