Results 81 to 90 of about 562,130 (302)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Begomovirus DNA-B Movement Protein and Nuclear Shuttle Protein Ref-Seq Datasets

, 2022
Multiple Sequence Alignment of proteins encoded on begomovirus DNA-B (movement protein and nuclear shuttle protein; n=131).
Siobain Duffy, J. Steen Hoyer, Divya Dubey   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cauliflower mosaic virus protein P6 inhibits signaling responses to salicylic acid and regulates innate immunity [PDF]

, 2012
Cauliflower mosaic virus (CaMV) encodes a multifunctional protein P6 that is required for translation of the 35S RNA and also acts as a suppressor of RNA silencing.
Loake, G.J., Byung-Wook Yun, Byung-Wook Yun (127536), Geri, Chiara, Chiara Geri, Gary J. Loake (127540), Milner, J.J., Laird, J., Ari Sadanandom, Yun, B.W., Craig Carr (127532), Janet Laird, Craig Carr, Milner, Joel J., Geri, C., Tada, Y., Joel J. Milner (127553), Carr, Craig, Andrew J Love, Sadanandom, Ari, Janet Laird (127528), Yun, Byung-Wook, Yasuomi Tada, Love, A.J., Yun, B.-W., Gary J Loake, Laird, Janet, Chiara Geri (127524), Yasuomi Tada (127544), Ari Sadanandom (127549), Carr, C., Love, Andrew J., Sadanandom, A., Andrew J. Love (104985), Loake, Gary J., Joel J Milner, Tada, Yasuomi   +36 more
core   +1 more source

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

npj Parkinson's Disease, 2023
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be ...
Sara Gomes, Alicia Garrido, Francesca Tonelli, Donina Obiang, Eduardo Tolosa, Maria José Martí, Javier Ruiz-Martínez, Ana Vinagre-Aragón, Haizea Hernandez-Eguiazu, Ioana Croitoru, Vicky L. Marshall, Theresa Koenig, Christoph Hotzy, Frank Hsieh, Marianna Sakalosh, Elizabeth Tengstrand, Shalini Padmanabhan, Kalpana Merchant, Christof Bruecke, Walter Pirker, Alexander Zimprich, Esther Sammler   +21 more
doaj   +1 more source

WUSCHEL protein movement and stem cell homeostasis [PDF]

Plant Signaling & Behavior, 2012
Stem cell maintenance is essential for growth and development of plants and animals. Similar to animal studies, transcription factors play a critical role in plant stem cell maintenance, however the regulatory logic is not well understood. Shoot apical meristems (SAMs) harbor a pool of pluoripotent stem cells and they provide cells for the development ...
Ram Kishor, Yadav, G Venugopala, Reddy
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement [PDF]

, 2010
Compartmentalization is an important process, since it allows the segregation of metabolic activities and, in the era of synthetic biology, represents an important tool by which defined microenvironments can be created for specific metabolic functions ...
Prentice, M.B., Mulvihill, D.P., Frank, S., Bhella, D., Frank, Stefanie, Parsons, J.B., Bhella, David, Prentice, Michael B., Liang, M., Mulvihill, Daniel P., Warren, Martin J., Parsons, Joshua B., Warren, M.J., Liang, Mingzhi   +13 more
core   +1 more source

CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB

, 2021
Background Molecular pathways associated with alpha-synuclein proteostasis have been detected in genetic studies and in cell models and include autophagy, ubiquitin-proteasome system, mitochondrial homeostasis, and synaptic plasticity.
Henrik Zetterberg, Blennow, Kaj,, Gasser, T., Zimmermann, M., Sjödin, Simon,, Wurster, I., Katharina Waniek, Lachmann, I., Kaj Blennow, Milan Zimmermann, Lerche, S., Ann‐Kathrin Hauser, Inga Liepelt‐Scarfone, Hauser, A. K., Simon Sjödin, Ann Brinkmalm, Isabel Wurster, Roeben, B., Brinkmalm, Ann,, Waniek, K., Zetterberg, Henrik,, Thomas Gasser, Stefanie Lerche, Liepelt-Scarfone, I., Brockmann, K., Kathrin Brockmann, Ingolf Lachmann, Benjamin Roeben   +27 more
core   +1 more source