Results 61 to 70 of about 562,130 (302)
Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]
, 2006 Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Complex movement disorders in a boy with PURA syndrome
, 2021 [[abstract]]PURA syndrome is a severe neurodevelopmental disorder named after its causative gene, the purine-rich element-binding protein A gene.
Lin, SJ;Lin, YF;Tsai, CH;Huang, CH;Ho, F;Tsai, SF;Lin, WS
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Chup1 - a chloroplast movement protein and its interactions [PDF]
, 2008 The molecular mechanisms of light dependent chloroplast movement could for a long time not be unravelled. But the recent discovery of a mutant deficient in chloroplast movement sparked new impulses in the field.
Schmidt von Braun, Serena
core
Virus-virus interactions alter the mechanical transmissibility and host range of begomoviruses
Frontiers in Plant Science, 2023 IntroductionBegomoviruses are mainly transmitted by whiteflies. However, a few begomoviruses can be transmitted mechanically. Mechanical transmissibility affects begomoviral distribution in the field.Materials and methodsIn this study, two mechanically ...
Ho-Hsiung Chang +4 more
doaj +1 more source
Sun Proteins Enlighten Nuclear Movement in Development [PDF]
Neuron, 2009 Regulation of nuclear movement is a critical event in neurogenesis and neuronal migration during brain development. In this issue of Neuron, Zhang et al. identify a role for SUN and the KASH-domain-containing nuclear membrane proteins as the long-sought linker between microtubules and the nucleus during brain development.
Koizumi, Hiroyuki, Gleeson, Joseph G.
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Size Dependence of Protein Diffusion in the Cytoplasm of Escherichia coli
, 2010 Diffusion in the bacterial cytoplasm is regarded as the primary method of intracellular protein movement and must play a major role in controlling the rates of cell processes.
Mastroianni, G +5 more
core +1 more source