Results 71 to 80 of about 562,130 (302)

Protein flexibility is key to cisplatin crosslinking in calmodulin [PDF]

, 2012
Chemical crosslinking in combination with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) has significant potential for studying protein structures and proteinprotein interactions.
Römer, Rudolf A., Sadler, P. J., Zhao, Yao, (Researcher in chemistry), O'Connor, Peter B., Jimenez-Roldan, J. Emilio, Wells, Stephen A., Li, Huilin   +6 more
core   +1 more source

The induction of stromule formation by a plant DNA-virus in epidermal leaf tissues suggests a novel intra- and intercellular macromolecular trafficking route

Frontiers in Plant Science, 2012
Stromules are dynamic thin protrusions of membrane envelope from plant cell plastids. Despite considerable progress in understanding the importance of certain cytoskeleton elements and motor proteins for stromule maintenance, their function within the ...
Björn eKrenz, Holger eJeske, Tatjana eKleinow   +2 more
doaj   +1 more source

Skeletal muscle proteome analysis underpins multifaceted mitochondrial dysfunction in Friedreich’s ataxia

Frontiers in Neuroscience, 2023
Friedreich’s ataxia (FRDA) is a severe multisystemic disorder caused by a deficiency of the mitochondrial protein frataxin. While some aspects of FRDA pathology are developmental, the causes underlying the steady progression are unclear.
Elisabetta Indelicato, Klaus Faserl, Matthias Amprosi, Wolfgang Nachbauer, Rainer Schneider, Julia Wanschitz, Bettina Sarg, Sylvia Boesch   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparison of the coat protein, movement protein and RNA polymerase gene sequences of Australian, Chinese, and American isolates of barley yellow dwarf virus transmitted by Rhopalosiphum padi

, 1998
Barley yellow dwarf luteovirus-GPV (BYDV-GPV) is a common problem in Chinese wheat crops but is unrecorded elsewhere. A defining characteristic of GPV is its capacity to be transmitted efficiently by both Schizaphis graminum and Rhopaloshiphum padi. This
Waterhouse, Peter M., Larkin, P. J., Wang, Ming-Bo, Keese, P., Graham, M. W., Cheng, Z.   +5 more
core   +1 more source

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source

Cellular Partners of Tobamoviral Movement Proteins

International Journal of Molecular Sciences
The size of viral genomes is limited, thus the majority of encoded proteins possess multiple functions. The main function of tobamoviral movement protein (MP) is to perform plasmodesmata gating and mediate intercellular transport of the viral RNA. MP is a remarkable example of a protein that, in addition to the initially discovered and most obvious ...
Natalia M. Ershova, Kamila A. Kamarova, Ekaterina V. Sheshukova, Tatiana V. Komarova   +3 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Movement and Specificity in a Modular DNA Binding Protein [PDF]

Structure, 2015
The single-stranded DNA (ssDNA) binding protein RPA binds to and protects ssDNA while simultaneously recruiting numerous replication and repair proteins essential for genome integrity. In this issue of Structure, Brosey et al. (2015) show that the flexibility and interactions of the modular domains of RPA are altered by ssDNA binding and suggest that ...
Liptak, Cary, Loria, J. Patrick
openaire   +2 more sources

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source