Results 41 to 50 of about 1,535,246 (311)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Collective action framing genetic engineering resistance in New Zealand [PDF]

, 2011
The genetic engineering resistance movement in New Zealand constructed strategic and meaningful interpretations of why the genetic engineering technique is problematic and what can be done about it.
Tucker, C
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Comparative analysis of biomechanical characteristics between the new Tai Chi elastic band exercise for opening and closing movement and elastic band resistance training for the reverse fly movement [PDF]

PeerJ
Background The objective of this study was to compare and analyze the representative opening and closing movement of Tai Chi elastic band exercise with the reverse fly movement of elastic band resistance training. The aim was to explore the biomechanical
Mingyu Liu, Cuihan Li, Xiongfeng Li, Jianwei Zhang, Haojie Li, Yameng Li, Qiuyang Wei, Zaihao Chen, Jiahao Fu, Yanying Li, Meize Cui, Lujia Li, Peng Zhang, Yuerong Huang, Yuxin Ma, Jianan Xu, Shaojun Lyu, Yunchao Ma   +17 more
doaj   +2 more sources

THE THOBE DRESS AS A NEW POLITICAL MOVEMENT AND FORM OF PALESTINIAN RESISTANCE

CMES (Center of Middle Eastern Studies), 2023
This research aims to analyze the issues of the new political movement and forms of Palestinian resistance through socio-cultural movements from the perspective of Sidney G. Tarrow.
Anna Zakiah Derajat, Toni Kurniawan
doaj   +1 more source

Globalising resistance: social movement activism in Malawi [PDF]

, 2011
Attendant with the rise of the good governance discourse of the 1990s and beyond, contemporary research on social activism in Africa has tended to be rooted in normalised conceptions of civil society operating in partnership with the state.
Gaynor, Niamh
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Estimation of energy efficiency of non-tractive rolling stock

Nauka ta progres transportu, 2013
Purpose. One of the priority areas for improving the transportation process by railway transport is to increase its energy efficiency. Preliminary quantitative assessment of the resistance of the creep forces wagon, determination of the influence of ...
A.N.Komarova, Y.P.Boronenko
doaj  

Cortical response characteristics of passive, active, and resistance movements: a multi-channel fNRIS study

Frontiers in Human Neuroscience
ObjectiveThis study aimed to explore the impact of exercise training modes on sensory and motor-related cortex excitability using functional near-infrared spectroscopy technology (fNIRS) and reveal specific cortical effects.Materials and methodsTwenty ...
Wenxi Li, Guangyue Zhu, Yichen Jiang, Cheng Miao, Guohui Zhang, Dongsheng Xu, Dongsheng Xu, Dongsheng Xu   +7 more
doaj   +1 more source