Results 71 to 80 of about 473,325 (286)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimal Length of Moving Average to Forecast Futures Basis [PDF]

Futures prices when combined with a basis forecast provide a reliable way to forecast cash prices. The most popular method of forecasting basis is historical moving averages. Given the recent failure of longer moving averages proposed by previous studies,
Anderson, Kim B., Brorsen, B. Wade, Hatchett, Robert B.   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nonparametric mixed exponentially weighted moving average-moving average control chart

Scientific Reports
AbstractThis research designed a distribution-free mixed exponentially weighted moving average-moving average (EWMA-MA) control chart based on signed-rank statistic to effectively identify changes in the process location. The EWMA-MA charting statistic assigns more weight to information obtained from the recent $$w$$ w
Muhammad Ali Raza, Azka Amin, Muhammad Aslam, Tahir Nawaz, Muhammad Irfan, F TARIQ   +5 more
openaire   +3 more sources

Projective stochastic equations and nonlinear long memory [PDF]

, 2013
A projective moving average $\{X_t, t \in \mathbb{Z}\}$ is a Bernoulli shift written as a backward martingale transform of the innovation sequence.
Grublytė, Ieva, Surgailis, Donatas
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Leveraging transfer learning with deep learning for crime prediction.

PLoS ONE
Crime remains a crucial concern regarding ensuring a safe and secure environment for the public. Numerous efforts have been made to predict crime, emphasizing the importance of employing deep learning approaches for precise predictions.
Umair Muneer Butt, Sukumar Letchmunan, Fadratul Hafinaz Hassan, Tieng Wei Koh   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Short‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundShort‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism.
Wenyuan Li, Elissa H. Wilker, Kirsten S. Dorans, Mary B. Rice, Joel Schwartz, Brent A. Coull, Petros Koutrakis, Diane R. Gold, John F. Keaney, Honghuang Lin, Ramachandran S. Vasan, Emelia J. Benjamin, Murray A. Mittleman   +12 more
doaj   +1 more source