Results 71 to 80 of about 475,199 (278)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Optimal Length of Moving Average to Forecast Futures Basis [PDF]

Futures prices when combined with a basis forecast provide a reliable way to forecast cash prices. The most popular method of forecasting basis is historical moving averages. Given the recent failure of longer moving averages proposed by previous studies,
Anderson, Kim B., Brorsen, B. Wade, Hatchett, Robert B.   +2 more
core   +1 more source

Nonparametric mixed exponentially weighted moving average-moving average control chart

Scientific Reports
AbstractThis research designed a distribution-free mixed exponentially weighted moving average-moving average (EWMA-MA) control chart based on signed-rank statistic to effectively identify changes in the process location. The EWMA-MA charting statistic assigns more weight to information obtained from the recent $$w$$ w
Muhammad Ali Raza, Azka Amin, Muhammad Aslam, Tahir Nawaz, Muhammad Irfan, F TARIQ   +5 more
openaire   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Leveraging transfer learning with deep learning for crime prediction.

PLoS ONE
Crime remains a crucial concern regarding ensuring a safe and secure environment for the public. Numerous efforts have been made to predict crime, emphasizing the importance of employing deep learning approaches for precise predictions.
Umair Muneer Butt, Sukumar Letchmunan, Fadratul Hafinaz Hassan, Tieng Wei Koh   +3 more
doaj   +1 more source

Short‐Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundShort‐term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism.
Wenyuan Li, Elissa H. Wilker, Kirsten S. Dorans, Mary B. Rice, Joel Schwartz, Brent A. Coull, Petros Koutrakis, Diane R. Gold, John F. Keaney, Honghuang Lin, Ramachandran S. Vasan, Emelia J. Benjamin, Murray A. Mittleman   +12 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Procedimiento para determinar las Tendencias Estadísticas del Desarrollo de la Competencia Investigativa del Ingeniero en Ciencias Informáticas (Procedure to Determinate the Statistical Trends of Development of Research Competence in Comp. Sci. Engineers)

GECONTEC: Revista Internacional de Gestión del Conocimiento y la Tecnología, 2014
Resumen En la Universidad de las Ciencias Informáticas de Cuba algunos estudiantes en su cuarto año académico de la carrera de ingeniería en ciencias informáticas se incorporan a los Centros de Desarrollo de Software y forman parte del equipo de ...
Odiel Estrada Molina, Misleydi Alfonso Pulido, Leonardo Hidalgo Iglesia, Sahara María Blanco Hernández, Febe Ángel Ciudad Ricardo   +4 more
doaj   +4 more sources