Results 41 to 50 of about 2,227,949 (244)

Crack Identification in Cantilever Beam under Moving Load Using Change in Curvature Shapes

open access: yesComputation, 2022
Cracks in structural components may ultimately lead to failure of the structure if not identified sufficiently early. This paper presents a crack-identification method based on time-domain.
Nutthapong Kunla   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Dynamics of a two-layer half-space with initial stresses under the impact of a moving load

open access: yesНауковий вісник Ужгородського університету. Серія: Математика і інформатика, 2022
In this article, within the framework of the linearized theory of elasticity for bodies with initial stresses, we consider a plane steady-state problem of perturbation of a two-layer half-space with an arbitrary form of elastic potential by a surface ...
С. Ю. Бабич   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Modeling of Flexible Multibody Systems Excited by Moving Loads with Application to a Robotic Portal System [PDF]

open access: yes, 2012
In this paper, an approach to solve mechanical problems with moving loads and flexible bodies is presented. Therefore, the multi-disciplinary modeling language Modelica together with the DLR FlexibleBodies Library is utilized.
Hartweg, Stefan, Heckmann, Andreas
core  

A new FEM procedure for transverse and longitudinal vibration analysis of thin rectangular plates subjected to a variable velocity moving load along an arbitrary trajectory

open access: yesLatin American Journal of Solids and Structures
A combined plate element is presented for the analysis of transverse and longitudinal vibrations of a thin plate which carries a load moving along an arbitrary trajectory with variable velocity.
İsmail Esen
doaj   +1 more source

Displacements of shell in soil-steel bridge subjected to moving load: determination using strain gauge measurements and numerical simulation

open access: yesStudia Geotechnica et Mechanica, 2022
This paper analyses displacements of a shell in a soil-steel bridge subjected to quasi-static moving loads. The considerations relate to a large span structure located in Ostróda, Poland.
Machelski Czesław   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Uniform asymptotic behaviour of integrals of Bessel functions with a large parameter in the argument [PDF]

open access: yes, 2010
Copyright @ The author 2010. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.orgIn this paper, we deal with integrals whose integrand has a rapidly oscillating zero-order ...
Voloshin, V   +5 more
core   +1 more source

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