Results 171 to 180 of about 6,633 (220)
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Ivermectin and moxidectin against soil-transmitted helminth infections
Trends in Parasitology, 2023Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged.
Eveline Hürlimann +2 more
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Presumed moxidectin toxicosis in three foals
Journal of the American Veterinary Medical Association, 1999Outcome and complications associated with administration of moxidectin gel to 3 foals < 4 months old are described. Two foals became comatose but survived following supportive treatment. One foal died following loss of consciousness associated with moxidectin administration. Risk of moxidectin overdose exists, because horse owners often fail to read or
P J, Johnson +3 more
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Analytical Profile of Moxidectin
2013Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and pharmaceutical aspects of moxidectin are described including stability, semisynthesis ...
Atul, Awasthi +4 more
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Journal of Agricultural and Food Chemistry, 1994
The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
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The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
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Parascaris equorum resistance to moxidectin?
Veterinary Record, 2008SIR, — With reference to the letter from Martin Peaty ( VR , March 22, 2008, vol 162, p 387), suggesting that moxidectin resistance may now be present in Parascaris equorum in the uk, there are a few points that need to be considered.
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Veterinary Parasitology, 1999
Ivermectin resistance in the nematode Haemonchus contortus has been reported in many parts of the world and many ivermectin resistant isolates have been found to have reduced sensitivity to moxidectin. However, it is unclear whether parasites that are selected with moxidectin would demonstrate reduced sensitivity to ivermectin.
M B, Molento, G T, Wang, R K, Prichard
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Ivermectin resistance in the nematode Haemonchus contortus has been reported in many parts of the world and many ivermectin resistant isolates have been found to have reduced sensitivity to moxidectin. However, it is unclear whether parasites that are selected with moxidectin would demonstrate reduced sensitivity to ivermectin.
M B, Molento, G T, Wang, R K, Prichard
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Responsible use of moxidectin in sheep
Veterinary Record, 2020SCOPS (sustainable control of parasites in sheep) and Zoetis held a joint workshop in September 2019 to discuss how to advise prescribers and sheep farmers on the use of moxidectin, and prioritising the 2 per cent injectable formulation. This was in response to concerns regarding reports of potential overuse, in particular, as a treatment for ewes at ...
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Depletion of Moxidectin Tissue Residues in Sheep
Journal of Agricultural and Food Chemistry, 2000The pattern of tissue depletion of moxidectin (MXD) subcutaneously administered to sheep was characterized in this study. MXD concentration profiles were determined in muscle, fat, and liver and at the site of injection following administration of a formulation combining MXD (0.5% w/v) with a standard 6 in 1 clostridial vaccine.
A, Lifschitz +6 more
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Pharmacokinetics of moxidectin and doramectin in goats
Research in Veterinary Science, 1999The pharmacokinetic behaviour of doramectin after a single subcutaneous administration and moxidectin following a single subcutaneous or oral drench were studied in goats at a dosage of 0.2 mg kg(-1). The drug plasma concentration-time data were analysed by compartmental pharmacokinetics and non-compartmental methods.
Escudero, E. +5 more
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Efficacy of moxidectin against cyathostomins
Veterinary Record, 2009It would be very encouraging if the report of [Schumacher and others (2009)][1] was a true indication of the lack of moxidectin resistance in horses after its use for five years in a heavily stocked pasture, but on the data presented I do not believe that this conclusion can be reached.
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