Results 71 to 80 of about 6,633 (220)

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

Evaluation of the Subchronic Toxicity of the Complex Preparation for Dogs and Cats "Inspector Kvadro" for Cutaneous Use

Российский паразитологический журнал, 2019
The purpose of the research is to assess the subchronic toxicity of the complex drug for dogs and cats “Inspector Kvadro” for cutaneous use.Materials and methods.
I. A. Stepanova, V. V. Artemov, G. B. Arisova, I. P. Belykh   +3 more
doaj   +1 more source

The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and Angiostrongylus vasorum infestation

Journal of Small Animal Practice, Volume 66, Issue 11, Page 797-807, November 2025.
Objectives Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document changes in tricuspid regurgitation maximum pressure gradient (TR Max PG) in subsequent months and years, record ...
R. Turner, D. Connolly, D. Brodbelt, S. Cortellini   +3 more
wiley   +1 more source

Efficacy and safety of moxidectin against strongyloidiasis

The Lancet Infectious Diseases
BACKGROUND: Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal dosing regimen remains unclear. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy and tolerability of different primaquine dosing regimens to prevent P vivax recurrence.
Luvira, V, Watthanakulpanich, D
openaire   +3 more sources

Pharmacokinetics of Intravenous and Transdermal Flunixin Meglumine in Wool and Hair Sheep (Ovis aries)

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 6, Page 484-490, November 2025.
ABSTRACT The objective of the study was to evaluate the pharmacokinetics of flunixin meglumine of intravenous (IV) and transdermal (TD) flunixin meglumine administration on different coat types (wool vs. hair) in 12 healthy sheep. Polled dorset (wool) sheep (n = 6) and katahdin (hair) sheep (n = 6) received 2.2 mg/kg IV and 3.3 mg/kg TD with a 10‐day ...
Kaitlyn G. Forrest, Jennifer L. Halleran, Ronald E. Baynes, Danielle A. Mzyk   +3 more
wiley   +1 more source

The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation.

PLoS Neglected Tropical Diseases
Moxidectin is approved by the US Food and Drug Administration (US FDA) for the treatment of onchocerciasis (river-blindness) due to Onchocerca volvulus in patients aged 12 years and older.
Nolan D Wood, Danelle Smith, Sally A Kinrade, Mark T Sullivan, Craig R Rayner, David Wesche, Kashyap Patel, Karen Rowland-Yeo   +7 more
doaj   +1 more source

Severe beak deformity in Melopsittacus undulatus caused by Knemidocoptes pilae [PDF]

, 2014
Se describe un brote de sarna Knemidocoptic causada por Knemidocoptes pilae en periquitos australianos enjaulados (Melopsittacus undulatus), del parque público de L'Eliana (Valencia, España).
Alarcón Elbal, Pedro María, Calero Bernal, Rafael, Carmona Salido, Víctor Jesús, Lucientes Curdi, Javier, Marín Sánchez-Murillo, José   +4 more
core   +2 more sources

ALOXE3 missense variant in a Chihuahua with autosomal recessive ichthyosis

Animal Genetics, Volume 56, Issue 5, October 2025.
Abstract Ichthyoses are a heterogenous group of inherited disorders that are characterized by excessive scale formation on the skin. We investigated a Chihuahua with severe scaling since age 12 weeks. The scaling was generalized and involved the entire body and legs. The paw pads were mildly hyperkeratotic.
Carina Vinberg, Stefan J. Rietmann, Sara Soto, Vidhya Jagannathan, Susanne Åhman, Tosso Leeb   +5 more
wiley   +1 more source

Factors affecting onchocerciasis transmission: Lessons for infection control [PDF]

, 2017
Introduction: Onchocerca volvulus infects in excess of 15 million people. The vectors are Simulium blackflies, varieties of which differ in their ecologies, behaviour and vectorial abilities.
Cheke, Robert A.
core   +1 more source

Moxidectin induces lethal autophagy arrest via CFTR

, 2022
Abstract Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence， developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo, This study aimed to elucidate the anti-CRC effect of MOX and its potential mechanism.
Yushan Mao, Hanhan Xie, Dan Shu, Lin Cheng, Jingbin Lan, Kejian Pan   +5 more
openaire   +1 more source