Results 1 to 10 of about 46,414 (181)

Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial [PDF]

Annals of Clinical Microbiology and Antimicrobials, 2010
Introduction Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments.
Tomić Monika, Bakula Vinko, Kućišec Nastja, Belošić-Halle Željka, Majstorović Karolina, Bago Josip, Bago Petra, Troskot Rosana   +7 more
doaj   +4 more sources

Towards human cardiac new approach methodologies (NAMs) to evaluate the combination of repolarization prolonging and shortening drugs: a pilot study [PDF]

Frontiers in Drug Discovery
Background and PurposeNonclinical human cardiac new approach methodologies (NAMs), including human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) combined with multielectrode array (MEA) represent a highly predictive in vitro model for ...
Robert M. Geiger, Carlos Serna, Bhavya Bhardwaj, Tromondae K. Feaster, Ksenia Blinova   +4 more
doaj   +2 more sources

Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness

Scientific Reports, 2021
To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity.
Dong Liang, Jing Ma, Bo Wei
doaj   +1 more source

Activity of Moxifloxacin Against Biofilms Formed by Clinical Isolates of Staphylococcus aureus Differing by Their Resistant or Persister Character to Fluoroquinolones

Frontiers in Microbiology, 2021
Staphylococcus aureus biofilms are poorly responsive to antibiotics. Underlying reasons include a matrix effect preventing drug access to embedded bacteria, or the presence of dormant bacteria with reduced growth rate.
Tiep K. Nguyen, Tiep K. Nguyen, Frédéric Peyrusson, Wafi Siala, Nhung H. Pham, Hoang A. Nguyen, Paul M. Tulkens, Françoise Van Bambeke   +7 more
doaj   +1 more source

Dose- and time-dependent manners of moxifloxacin induced liver injury by targeted metabolomics study

Frontiers in Pharmacology, 2022
Moxifloxacin is the most widely prescribed antibiotics due to its excellent oral bioavailability and broad-spectrum antibacterial effect. Despite of its popularity, the rare and severe liver injury induced by moxifloxacin is a big concern that cannot be ...
Ting Hu, Yuan Sun, Zhuoling An
doaj   +1 more source

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3 [PDF]

, 2013
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB.
A Hill, A Koul, AE Grzegorzewicz, Alfonso Mendoza-Losana, Anil Kumar Tyagi, C Dye, C Varela, Carlos Alemparte, Carolina González, Chrystala Constantinidou, CK Stover, David Barros, David J. Dow, DJ Payne, Douglas J. Minick, Elena Jiménez, Esther Pérez-Herrán, Fátima Ortega-Muro, Gurdyal S. Besra, Iñigo Angulo-Barturen, JA Maddry, Joaquín Rullás, Johnson Afari, Jorge Esquivias, K Andries, K Pethe, K Tahlan, LL Ballell, Lluís Ballell, M Berry, M Biava, M Murray, M Protopopova, Mark J. Pallen, María José Rebollo-López, María Martínez-Hoyos, María Teresa Fraile-Gabaldón, Modesto J. Remuiñán, Mónica Cacho, Nalini Mehta, Nicholas Cammack, Nicholas J. Loman, R Singh, SA Stanley, ST Cole, V La Rosa, V Makarov, Verónica Sousa, Vickey L. Spivey   +48 more
core   +13 more sources

Comparative Outcomes of Standard Perioperative Eye Drops, Intravitreal Triamcinolone Acetonide-Moxifloxacin, and Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surgery

Journal of Ophthalmology, 2022
Background. Since the advent of cataract surgery, topical eye drops have been the mainstay of postoperative prophylaxis and treatment. Due to factors such as high expenses and poor patient compliance, there has been a growing interest and acceptance of ...
Robin K. Kuriakose, Soungmin Cho, Saman Nassiri, Frank S. Hwang   +3 more
doaj   +1 more source

Strategies for treating latent multiple-drug resistant tuberculosis: a decision analysis. [PDF]

PLoS ONE, 2012
The optimal treatment for latent multiple-drug resistant tuberculosis infection remains unclear. In anticipation of future clinical trials, we modeled the expected performance of six potential regimens for treatment of latent multiple-drug resistant ...
David P Holland, Gillian D Sanders, Carol D Hamilton, Jason E Stout   +3 more
doaj   +1 more source

Mycobacterium smegmatis strains genetically resistant to moxifloxacin emerge de novo from the moxifloxacin-surviving population containing high levels of superoxide, H2O2, hydroxyl radical, and Fe (II)

International Journal of Mycobacteriology, 2022
Background: The antibiotic-exposed bacteria often contain the reactive oxygen species (ROS), hydroxyl radical, which inflicts genome-wide mutations, causing the de novo formation of antibiotic-resistant strains.
Avraneel Paul, Rashmi Ravindran Nair, Kishor Jakkala, Parthasarathi Ajitkumar   +3 more
doaj   +1 more source

Moxifloxacin: safety profile

Медицинский совет, 2013
The latest, so-called respiratory, fluoroquinolones are a group of antimicrobial agents (AMA), most commonly prescribed for community-acquired lower respiratory tract infection (caLRTI), which is a relevant issue in routine clinical practice.
A. I. Sinopalnikov
doaj   +1 more source