Results 11 to 20 of about 39,119 (216)

Fluoroquinolone-Associated Psychiatric and Ocular Adverse Events: A Disproportionality Analysis Using Real-World Data From FAERS (2011-2024). [PDF]

Pharmacol Res Perspect
This pharmacovigilance study identifies a wide range of rapid‐onset neuropsychiatric and ocular adverse effects linked to fluoroquinolones (FQ). Disproportionality analysis revealed a disproportionate reporting of suicidal ideation and visual impairment following FQ treatment, emphasizing the urgent need for cautious prescribing and strengthened safety
Chau HT, Au NPB.
europepmc   +2 more sources

Comparative Outcomes of Standard Perioperative Eye Drops, Intravitreal Triamcinolone Acetonide-Moxifloxacin, and Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surgery

Journal of Ophthalmology, 2022
Background. Since the advent of cataract surgery, topical eye drops have been the mainstay of postoperative prophylaxis and treatment. Due to factors such as high expenses and poor patient compliance, there has been a growing interest and acceptance of ...
Robin K. Kuriakose, Soungmin Cho, Saman Nassiri, Frank S. Hwang   +3 more
doaj   +1 more source

Strategies for treating latent multiple-drug resistant tuberculosis: a decision analysis. [PDF]

PLoS ONE, 2012
The optimal treatment for latent multiple-drug resistant tuberculosis infection remains unclear. In anticipation of future clinical trials, we modeled the expected performance of six potential regimens for treatment of latent multiple-drug resistant ...
David P Holland, Gillian D Sanders, Carol D Hamilton, Jason E Stout   +3 more
doaj   +1 more source

Mycobacterium smegmatis strains genetically resistant to moxifloxacin emerge de novo from the moxifloxacin-surviving population containing high levels of superoxide, H2O2, hydroxyl radical, and Fe (II)

International Journal of Mycobacteriology, 2022
Background: The antibiotic-exposed bacteria often contain the reactive oxygen species (ROS), hydroxyl radical, which inflicts genome-wide mutations, causing the de novo formation of antibiotic-resistant strains.
Avraneel Paul, Rashmi Ravindran Nair, Kishor Jakkala, Parthasarathi Ajitkumar   +3 more
doaj   +1 more source

Moxifloxacin pharmacokinetics, cardiac safety, and dosing for the treatment of rifampicin-resistant tuberculosis in children.

Clinical Infectious Diseases, 2021
BACKGROUND Moxifloxacin is a priority recommended drug for rifampin-resistant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic and safety data, especially in young children.
Kendra K. Radtke, A. Hesseling, J. Winckler, H. Draper, B. P. Solans, S. Thee, L. Wiesner, L. E. van der Laan, B. Fourie, James Nielsen, H. S. Schaaf, R. Savic, A. Garcia-Prats   +12 more
semanticscholar   +1 more source

Strong Increase in Moxifloxacin Resistance Rate among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China, 2007 to 2013

Microbiology spectrum, 2021
China is one of the high-burden countries for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). Moxifloxacin is one of the critical antituberculosis drugs for MDR/RR-TB treatment. ABSTRACT We designed this study to determine the trend of
H. Xia, Yang Zheng, Dong-xin Liu, Shengfen Wang, Wen-cong He, B. Zhao, Yuanyuan Song, X. Ou, Yang Zhou, S. van den Hof, F. Cobelens, Yanlin Zhao   +11 more
semanticscholar   +1 more source

Moxifloxacin Activates the SOS Response in Mycobacterium tuberculosis in a Dose- and Time-Dependent Manner

Microorganisms, 2021
Previous studies on Escherichia coli demonstrated that sub-minimum inhibitory concentration (MIC) of fluoroquinolones induced the SOS response, increasing drug tolerance.
A. Iacobino, G. Piccaro, M. Pardini, L. Fattorini, F. Giannoni   +4 more
semanticscholar   +1 more source

A randomized, controlled, multicenter clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus moxifloxacin in adult patients with community-acquired pneumonia

Current Medical Research and Opinion, 2021
Objectives To evaluate the efficacy and safety of oral sitafloxacin versus oral moxifloxacin in the treatment of Chinese adults with community-acquired pneumonia (CAP).
Ying Li, Demei Zhu, Yiqiang Peng, Z. Tong, Zhuang Ma, Jinfu Xu, Sheng-hua Sun, Huaping Tang, Q. Xiu, Yongjie Liang, Xiongbiao Wang, X. Lv, Yuanrong Dai, Yingqun Zhu, Yuejin Qu, Kaifeng Xu, Yijiang Huang, Shiman Wu, Guoxiang Lai, Xi Li, Xiaowen Han, Zegang Yang, J. Sheng, Zhuola Liu, Hui Li, Yiqiang Chen, Huili Zhu, Yingyuan Zhang   +27 more
semanticscholar   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Resistance-guided antimicrobial therapy using doxycycline-moxifloxacin and doxycycline-2.5g azithromycin for the treatment of Mycoplasma genitalium infection: efficacy and tolerability.

Clinical Infectious Diseases, 2020
BACKGROUND Macrolide-resistance in Mycoplasma genitalium (MG) exceeds 50% in many regions and quinolone-resistance is increasing. We recently reported that resistance-guided therapy (RGT) using doxycycline followed by sitafloxacin or 2.5g-azithromycin ...
Duygu Durukan, T. Read, G. Murray, Michelle Doyle, E. Chow, L. Vodstrcil, C. Fairley, I. Aguirre, E. Mokany, L. Tan, Marcus Y. Chen, C. Bradshaw   +11 more
semanticscholar   +1 more source