Results 31 to 40 of about 39,119 (216)

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance New antibacterials are needed to treat community-acquired bacterial pneumonia (CABP) because of growing antibacterial resistance and safety concerns with standard care.
E. Alexander, L. Goldberg, Anita F. Das, G. Moran, C. Sandrock, L. Gasink, Patricia Spera, Carolyn Sweeney, S. Paukner, W. Wicha, S. Gelone, J. Schranz   +11 more
semanticscholar   +1 more source

Emergence and spread of moxifloxacin-resistant Clostridium difficile ribotype 231 in Sweden between 2006 and 2015

New Microbes and New Infections, 2016
An aggregation of moxifloxacin-resistant Clostridium difficile ribotype 231 (RT231) isolates was first identified in the county of Stockholm in 2008, and by the end of 2015 isolates of RT231 had spread to 13 of 21 Swedish counties.
H. Harvala, E. Alm, T. Åkerlund, K. Rizzardi   +3 more
doaj   +1 more source

Two nitazoxanide-based quadruple regimens for eradication of Helicobacter pylori infection: a single-center randomized controlled trial

Al-Azhar Assiut Medical Journal, 2022
Background and aim Eradication of Helicobacter pylori becomes an ongoing challenge worldwide because eradication rates of H. pylori are declining to less than 60% in some countries.
Amro M Hassan, Khaled Eid, Khaled A.M Eliwa, Muhammad Abdel-Gawad   +3 more
doaj   +1 more source

Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and Pharmacokinetic Study in Rabbits

Pharmaceutics, 2019
Nanoemulsion is one of the potential drug delivery strategies used in topical ocular therapy. The purpose of this study was to design and optimize a nanoemulsion-based system to improve therapeutic efficacy of moxifloxacin in ophthalmic delivery ...
Jigar N. Shah, Anroop B Nair, S. Jacob, Rakesh K Patel, Hiral Shah, Tamer M. Shehata, M. Morsy   +6 more
semanticscholar   +1 more source

Endophthalmitis prophylaxis study. Report 1: Intracameral cefuroxime and moxifloxacin prophylaxis for the prevention of postcataract endophthalmitis in rural India

Indian Journal of Ophthalmology, 2020
Purpose: Intracameral antibiotics are known to reduce the incidence of acute endophthalmitis. Various drugs are available for intracameral use. This prospective study was carried out to compare the efficacies of intracameral cefuroxime and moxifloxacin ...
V. Rathi, Savitri Sharma, T. Das, R. Khanna   +3 more
semanticscholar   +1 more source

HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia

Journal of Diabetes Research, 2016
The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry.
Hai-Yan Qiu, Sha-Sha Yuan, Fang-Yuan Yang, Ting-Ting Shi, Jin-Kui Yang   +4 more
doaj   +1 more source

Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin

European Respiratory Journal, 2020
The World Health Organization (WHO) has listed moxifloxacin and linezolid among the preferred “group A” drugs in the treatment of multidrug-resistant (MDR)-tuberculosis (TB) [1]. Therapeutic drug monitoring (TDM) could potentially optimise MDR-TB therapy,
Simone H. J. van den Elsen, O. Akkerman, Erwin M. Jongedijk, Mireille A. Wessels, S. Ghimire, T. S. van der Werf, D. Touw, M. Bolhuis, J. Alffenaar   +8 more
semanticscholar   +1 more source

Moxifloxacin monotherapy versus combination therapy in patients with severe community-acquired pneumonia evoked ARDS

BMC Anesthesiology, 2017
Background We tested the hypothesis that moxifloxacin monotherapy is equally effective and safe as a betalactam antibiotic based combination therapy in patients with acute respiratory distress syndrome (ARDS) evoked by severe community acquired pneumonia
Tim Rahmel, Sven Asmussen, Jan Karlik, Jörg Steinmann, Michael Adamzik, Jürgen Peters   +5 more
doaj   +1 more source

Moxifloxacin promotes two-photon microscopic imaging for discriminating different stages of DSS-induced colitis on mice

Photodiagnosis and Photodynamic Therapy
Background: Accurate diagnosis of patients with ulcerative colitis (UC) can reduce their risk of developing colorectal cancer. This study intended to explore whether moxifloxacin, an agent with fluorescence potential, could promote two-photon microscopy (
Yingtong Chen, Xiaoyi Xu, Min Wang, Xiang Wang, Yan Wang, Yong Zhang, Jin Huang, Yuwen Tao, Wentao Fan, Lili Zhao, Li Liu, Zhining Fan   +11 more
doaj   +1 more source

Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis

Antimicrobial Agents and Chemotherapy, 2019
Novel regimens combining bedaquiline and pretomanid with either linezolid (BPaL regimen) or moxifloxacin and pyrazinamide (BPaMZ regimen) shorten the treatment duration needed to cure tuberculosis (TB) in BALB/c mice compared to that of the first-line ...
Jian Xu, Si-yang Li, Deepak Almeida, R. Tasneen, Kala Barnes-Boyle, P. Converse, A. Upton, K. Mdluli, N. Fotouhi, E. Nuermberger   +9 more
semanticscholar   +1 more source