Results 51 to 60 of about 39,119 (216)

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Activity of Antimicrobial Combinations Against Extensively Drug-Resistant Acinetobacter baumannii as Determined by Checkerboard Method and E-test

Siriraj Medical Journal, 2020
Objective: Combination therapy is needed to treat extensively drug-resistant (XDR) Acinetobacter baumannii infection. Colistin (Col) in combination with another drug is usually used for that purpose. The aim of this study was to determine the activity of
Sunee Limsrivanichakorn, Popchai Ngamskulrungroj, Amornrut Leelaporn   +2 more
doaj   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

A rare case of Bordetella avium pneumonia complicated by Raoultella planticola

Clinical Case Reports, 2020
Bordetella avium pneumonia immunocompromised the patient with subsequent complication by a rare opportunistic Raoultella planticola infection, which became a nosocomial pathogen in the healthcare setting.
Anna Lavrenko, Nataliia Digtiar, Nataliia Gerasymenko, Igor Kaidashev   +3 more
doaj   +1 more source

Characteristics and Clinical Outcomes of Patients With Hidradenitis Suppurativa (HS) Treated With Bimekizumab: A Canadian Retrospective Chart Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterised by painful nodules, abscesses, and draining and non‐draining tunnels. Currently, there are two biologics approved in Canada for the treatment of moderate‐to‐severe HS, adalimumab (anti‐TNF) and secukinumab (anti‐IL‐17A).
Irina Turchin, Tracey Brown‐Maher, Hélène Veillette, David O. Croitoru, Kyle Cullingham   +4 more
wiley   +1 more source

Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin

Antibiotics
Sepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades.
Tiago R. Velho, Helena Raquel, Nuno Figueiredo, Ana Neves-Costa, Dora Pedroso, Isa Santos, Katharina Willmann, Luís F. Moita   +7 more
doaj   +1 more source

Fluoroquinolonas en humor acuoso en pacientes sometidos a cirugía de catarata.

Revista GICOS, 2021
Los procesos infecciosos como la endoftalmitis postquirúrgica sigue siendo una de las complicaciones más devastadoras de la cirugía de cataratas, por tal motivo el uso de antibióticos de amplio espectro, evitarían o tratarían de disminuir estas ...
Argilio Duran, Pedro Rivas, Yasmin Morales, Ambar Rodríguez   +3 more
doaj  

Simultaneous determination of moxifloxacin and H2 receptor antagonist in pharmaceutical dosage formulations by RP-HPLC: application to in vitro drug interactions

Química Nova, 2011
Simultaneous determination of moxifloxacin (MOX) and H2-antagonists was first time developed in bulk and formulations. Purospher STAR C18 (250 x 4.6 mm, 5 μm) column was used.
Najma Sultana, Mahwish Akhtar, Sana Shamim, Somia Gul, Muhammad Saeed Arayne   +4 more
doaj   +1 more source

Mutations in ParC and GyrA of moxifloxacin-resistant and susceptible Mycoplasma genitalium strains

PLoS ONE, 2018
Macrolide or fluoroquinolone-resistant Mycoplasma genitalium is spreading worldwide. We aimed to determine the influence of single nucleotide polymorphisms (SNPs) in the quinolone resistance determining regions (QRDR) of parC and gyrA in cultured M ...
R. Hamasuna, P. Le, S. Kutsuna, K. Furubayashi, M. Matsumoto, N. Ohmagari, N. Fujimoto, Tetsurou Matsumoto, J. Jensen   +8 more
semanticscholar   +1 more source