Results 81 to 90 of about 278,558 (314)

Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies

PLoS ONE, 2018
Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen.
Harald Kratz, M. Taupitz, Angela Ariza de Schellenberger, O. Kosch, D. Eberbeck, S. Wagner, L. Trahms, B. Hamm, J. Schnorr   +8 more
semanticscholar   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Implementation of the parallel mean shift-based image segmentation algorithm on a GPU cluster

International Journal of Digital Earth, 2019
The mean shift image segmentation algorithm is very computation-intensive. To address the need to deal with a large number of remote sensing (RS) image segmentations in real-world applications, this study has investigated the parallelization of the mean ...
Fang Huang, Yinjie Chen, Li Li, Ji Zhou, Jian Tao, Xicheng Tan, Guangsong Fan   +6 more
doaj   +1 more source

Restless bandit marginal productivity indices I: singleproject case and optimal control of a make-to-stock M/G/1 queue [PDF]

, 2004
This paper develops a framework based on convex optimization and economic ideas to formulate and solve by an index policy the problem of optimal dynamic effort allocation to a generic discrete-state restless bandit (i.e. binary-action: work/rest) project,
Niño Mora, José
core   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Forced expression of MSR repeat transcripts above a threshold limit breaks heterochromatin organisation

Nature Communications
Mouse heterochromatin is characterised by transcriptionally competent major satellite repeat (MSR) sequences and it has been proposed that MSR RNA contributes to the integrity of heterochromatin.
Reagan W. Ching, Kalina M. Świst-Rosowska, Galina Erikson, Birgit Koschorz, Bettina Engist, Thomas Jenuwein   +5 more
doaj   +1 more source

Minimum entropy production by microswimmers with internal dissipation

Nature Communications, 2023
The energy dissipation and entropy production by self-propelled microswimmers differ profoundly from passive particles pulled by external forces.
Abdallah Daddi-Moussa-Ider, Ramin Golestanian, Andrej Vilfan   +2 more
doaj   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Precise determination of αS( m Z 0 $ m_{Z^0 } $ ) from a global fit of energy-energy correlations to NNLO+NNLL predictions [PDF]

EPJ Web of Conferences, 2019
We present a determination of the strong coupling constant αS( m Z 0 $ m_{Z^0 } $ ) using a global fit of theory predictions in next-to-next-next-leading-order (NNLO) combined with resummed predictions at the next-to-next-leading-log level (
Kardos A., Kluth S., Somogyi G., Tulipánt Z., Verbytskyi A.   +4 more
doaj   +1 more source

HIDF: Integrating Tree‐Structured scRNA‐seq Heterogeneity for Hierarchical Deconvolution of Spatial Transcriptomics

Advanced Science, EarlyView.
The prevailing neglect of cellular hierarchies in current spatial transcriptomics deconvolution often obscures cellular heterogeneity and impedes the identification of fine‐grained subtypes. To address this issue, HIDF employs a cluster‐tree and dual regularization to systematically model cellular hierarchical structures.
Zhiyi Zou, Yuting Bai, Bo Wang, Wanwan Shi, Xiao Liang, Jiawei Luo   +5 more
wiley   +1 more source