Results 91 to 100 of about 36,802 (283)
Bleeding complications in \(\it bcr-abl\)-negative myeloproliferative neoplasms (MPN)
, 2021 In patients with \(\it bcr-abl\)-negative myeloproliferative neoplasms (MPN), concerns are often raised about the use of anticoagulants because of an increased bleeding risk. However, there are few MPN studies focusing on bleeding.Marchi, Hannah (M. Sc.), Griesshammer, Martin (Prof. Dr. med.), Sadjadian, Parvis (Dr. med.), Wille, Kai (Dr. med.), Fuchs, Christiane (Prof. Dr. rer. nat.), Kolatzki, Vera, Hünerbein, Karlo R. (Dr. med.), Jagenberg, Ellen, Meixner, Raphael (M. Sc.), Becker, Tatjana +9 morecore +1 more sourceMyeloproliferative (MPN) Symptom Burden Response Thresholds: Assessment Of MPN-SAF TSS Quartiles As Potential Markers Of Symptom Response
Background
We have previously reported on the significant, but heterogeneous baseline MPN symptom burden among an international sample of MPN patients (including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (Mesa, Ruben A., Commandeur, Suzan, Johansson, Peter, Barbui, Tiziano, Boekhorst, Peter te, Zweegman, Sonja, Ranta, Dana, Birgegard, Gunnar, Stegelmann, Frank, Doehner, Konstanze, Sun, Xiujuan, Fuentes, Ana Kerguelen, Boyer, Françoise, Geyer, Holly Lynn, Emanuel, Robyn M., Slot, Stephanie, Schouten, Harry C., Ferrari, Maria, Etienne, Gabriel, Barosi, Giovanni, Rambaldi, Alessandro, Cervantes, Francisco, Tefferi, Ayalew, Cahn, Jean-Yves, Muxi, Pablo J., Pahl, Heike L., Zhang, Peihong, Dueck, Amylou Constance, Lehmann, Thomas, Xu, Zefeng, Samuelsson, Jan, Xiao, Zhijian, Harrison, Claire N, Maldonado, Norman I, Roy, Lydia, Griesshammer, Martin, Xu, Junqing, Sackmann, Federico, Hernandez, Dolores, Passamonti, Francesco, Reiter, Andreas, Kiladjian, Jean-Jacques, Andreasson, Bjorn, Gale, Robert Peter, Ianotto, Jean-Christophe, Bonatz, Karin, Zhang, Yue, Vannucchi, Alessandro M, Radia, Deepti H, Besses, Carlos +49 morecore +1 more sourceSchematic illustration for MPN-HBP1-mediated anticancer therapy.
, 2023 The PEI-HBP1 coordinates with tannic acid and ferric ions to form MPN-HBP1. After MPN-HBP1 nanoparticles reach the tumor site via passive targeting, the tannic acid and ferric ions in the MPN coating enhance the Fenton reaction to induce ferroptosis in ...Xiaowei Zhang (6505), Jiyin Wang (10453367), Yue Zhou (71752), Ruixiang Yang (10453370), Shujie Wang (750318), Yuning Cheng (9303610), Tongjia Zhang (16496661), Zhe Yang (8942), Hui Li (32376), Wei Jiang (14986) +9 morecore +1 more sourceAntimicrobial bilayer starch film containing zein electrospun fibers encapsulating thyme essential oil for cherry tomato packaging
Journal of the Science of Food and Agriculture, EarlyView.Abstract Background
This study evaluated the antimicrobial activity of thyme essential oil (TEO) encapsulated in electrospun zein fibers for use in bilayer films as active packaging for cherry tomatoes. The antimicrobial activity of TEO and bilayer films with 20%, 40%, and 60% TEO was assessed with agar diffusion and microatmosphere assays.Jéssica Silveira Vitoria, Tamires Soares Schug, Laura Martins Fonseca, Débora A. Campos, Manuela Pintado, Tatiane Kuka Valente Gandra, Elessandra da Rosa Zavareze, Eliezer Avila Gandra +7 morewiley +1 more sourceInsomnia, Quality Of Life and MPN Symptom Burden: An Analysis By The MPN Quality Of Life International Study Group (MPN-QOL ISG)
Background
We have previously reported on the high prevalence and severity of insomnia amongst a large international cohort of MPN patients (Emanuel JCO 2012).Mesa, Ruben A., Commandeur, Suzan, Johansson, Peter, Barbui, Tiziano, Zweegman, Sonja, Ranta, Dana, Peter Gale, Robert Peter, Birgegard, Gunnar, Stegelmann, Frank, Sun, Xiujuan, Fuentes, Ana Kerguelen, Boyer, Françoise, Geyer, Holly Lynn, Emanuel, Robyn M., Slot, Stephanie, Schouten, Harry C., Ferrari, Maria, Etienne, Gabriel, Barosi, Giovanni, Rambaldi, Alessandro, Cervantes, Francisco, Cahn, Jean-Yves, Muxi, Pablo J., Pahl, Heike L., Zhang, Peihong, Dueck, Amylou Constance, Lehmann, Thomas, Xu, Zefeng, Samuelsson, Jan, Xiao, Zhijian, Harrison, Claire N, Maldonado, Norman I, Boekhorst, Peter, Griesshammer, Martin, Roy, Lydia, Xu, Junqing, Dohner, Konstanze, Sackmann, Federico, Passamonti, Francesco, Reiter, Andreas, Kiladjian, Jean-Jacques, Andreasson, Bjorn, Cannon, Keith, Ianotto, Jean-Christophe, Bonatz, Karin, Zhang, Yue, Hernández-Maraver, Dolores, Radia, Deepti H, Besses, Carlos, Vannucchi, Alessandro M. +49 morecore +1 more sourceJAMM/MPN+-MPN− assembly.
, 2014 (A,B,C) Ins-1 conformation and UBL binding. Residues discussed in the text are shown in stick mode and the zinc-coordinating residues in purple. Bottom panel: 90° rotated view with respect to the top panel. (A) AMSH-LP MPN Ins-1 bound to distal ubiquitin.Melissa Birol (619685), Stéphane Betzi (279166), Ruedi Aebersold (3175), Yinshan Yang (619687), Aude Echalier (619690), Christian Dumas (619689), André Padilla (486817), François Hoh (619688), Radoslav Ivanov Enchev (619686), Florian Stengel (428563), Matthias Peter (88085) +10 morecore +1 more sourceJAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?
Movement Disorders Clinical Practice, EarlyView.Abstract Background
JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia +5 morewiley +1 more sourceCluster analysis of inflammatory gene expression in MPN patients.
, 2019 (A) Hierarchical clustering separates MF grade 0–1 MPN from MF grade 2–3 MPN in a training cohort of 76 patients. (B) K-means clustering (k = 4) separates prefibrotic (MF grade 0–1) disease from overtly fibrotic disease (MF grade 2–3). Four clusters with Olga Pozdnyakova (3585275), Michele Baltay (6685274), Annaliese Getz (6685277), Waihay J. Wong (6685271), Robert P. Hasserjian (6685283), Kit Fuhrman (6685280), Jon C. Aster (201399) +6 morecore +1 more sourceCannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial
Movement Disorders, EarlyView.Abstract Background
There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective
To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods
This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade +14 morewiley +1 more source