Results 81 to 90 of about 36,802 (283)

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Coexistence of BCR::ABL1 translocation and JAK2V617F mutations in indian patients with myeloproliferative neoplasms: A case series

Indian Journal of Pathology and Microbiology
BCR::ABL1 translocation and JAK2V617F mutations are canonical variants of myeloproliferative neoplasms (MPNs). Traditionally considered mutually exclusive, they may rarely coexist.
Durgadevi Sundaresan, Debadrita Ray, Amarjot Kaur, Charanpreet Singh, Nithye Parvathy, Alpesh Kapadia, Riju Rani Deka, Narender Kumar, Jogeshwar Binota, Pankaj Malhotra, Shano Naseem, Praveen Sharma   +11 more
doaj   +1 more source

Development of resistance to type II JAK2 inhibitors in MPN depends on AXL kinase and is targetable. [PDF]

PURPOSE Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Since clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest.
Codilupi, Tamara, Buczak, Katarzyna, Levine, Ross L, Jungius, Sarah, Dirnhofer, Stephan, Rovo, Alicia, Ghosh, Nilabh, Szybinski, Jakub, Stivala, Simona, Arunasalam, Stefanie, Koche, Richard, Albrecht, Camille, Vokalova, Lenka, Meyer, Sara C, Dirnhofer, Stefan, Passweg, Jakob R, Yang, Julie L, Pankov, Dmitry, Dunbar, Andrew C, Angelillo-Scherrer, Anne, Brkic, Sime   +20 more
core   +2 more sources

Activated carbons made from cocoa (Theobroma cacao) and coconut (Cocos nucifera) shells can be used as adsorbents to improve the quality of frying oils

Food Biomacromolecules, EarlyView.
Carbonised cocoa shells and carbonised coconut shells have a high level of porosity and a large adsorption surface area. Activated carbons made from cocoa and from the mixture cocoa–coconut shells at 15% demonstrated their ability to reduce primary and secondary oxidation products in frying oils and improves the organoleptic properties of fried foods ...
Gires Boungo Teboukeu, Prudent Ngabe Mituga, Ghislain Tazoho Maffo, Georges Teikam Kenda, Ronice Zokou, Archelle Abaobo Foudjin, Hilaire Macaire Womeni   +6 more
wiley   +1 more source

Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT A whole‐body mechanistic PBPK model for meropenem (MPN) was developed in PK‐Sim and validated using published plasma and tissue concentration–time data in healthy volunteers and critically ill patients. Renal elimination was implemented as glomerular filtration plus active tubular secretion (basolateral uptake via OAT3 with apical efflux), and
Olivo LB, de Lemos JLS, Rodrigues VJ, de Araújo BV.   +3 more
europepmc   +2 more sources

Diagnosis and Management of Polycythemia Vera Complicated by Cerebral Infarction and Subdural Hematoma: A Case Report

iLABMED, EarlyView.
A 70‐year‐old man with recurrent cerebral infarctions, a subdural hematoma, and atherosclerotic disease involving multiple extracranial vascular territories was subsequently diagnosed with polycythemia vera (PV). In patients with recurrent cerebrovascular events accompanied by otherwise unexplained persistent erythrocytosis, JAK2 mutation testing and ...
Hui Zhao, Jie Feng, Yu Jing, Wei Xie, Yingjiao Sha, Yanhong Gao   +5 more
wiley   +1 more source

Mutations in MPNs to “interfere-on” [PDF]

Blood, 2021
openaire   +2 more sources

Myeloproliferative neoplasms (MPNs) – Part 1: An overview of the diagnosis and treatment of the “classical” MPNs

Canadian Oncology Nursing Journal, 2018
Myeloproliferative neoplasms (MPNs) are rare, yet potentially life-threatening, disorders caused by overproliferation of bone marrow stem cells. The symptom burden experienced by patients with the BCR-ABL1-negative MPNs (also referred to as the classical MPNs, i.e., essential thrombocythemia [ET], polycythemia vera [PV] and myelofibrosis [MF]) can be ...
Sabrina, Fowlkes, Cindy, Murray, Adrienne, Fulford, Tammy, De Gelder, Nancy, Siddiq   +4 more
openaire   +3 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Biosurfactant‐assisted recovery and remediation of hydrocarbons from oily sludge using a mobile aerated washing system

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The oil industry generates oily sludge, the accumulation of which poses a serious environmental problem. Conventional methods require high costs, specialized equipment, and qualified personnel. This waste can be treated using biosurfactants.
Maria Eduarda Pereira da Silva, Fabíola Carolina Gomes de Almeida, Gabriel Neves da Motta Silveira, Bruno Humberto de Almeida Silva, Maria da Glória Conceição da Silva, Celmy Maria Bezerra de Menezes Barbosa, Leonie Asfora Sarubbo   +6 more
wiley   +1 more source