Results 61 to 70 of about 36,802 (283)

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation

OncoImmunology, 2018
Compelling evidence supports the existence of a profound immune dysregulation in patients with chronic myeloproliferative neoplasms (MPN). Increased Arginase-1 expression has been described in MPN patients and in solid cancers.
Mia Aaboe Jørgensen, Morten Orebo Holmström, Evelina Martinenaite, Caroline Hasselbalch Riley, Hans Carl Hasselbalch, Mads Hald Andersen   +5 more
doaj   +1 more source

Early MPN detection in laboratory setting

, 2023
Myeloproliferative Neoplasms (MPNs) are a group of bone marrow diseases with potentially lethal cardio-vascular complications. Two sub-diseases of MPN are Essential Thrombocytosis (ET) and Polycythemia Vera (PV), which are recognised by an abnormal blood
Nijsse, Paul (author)
core  

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Comparison of recognition of symptom burden in MPN between patient- and physician-reported assessment - an intraindividual analysis by the German Study Group for MPN (GSG-MPN) [PDF]

Myeloproliferative neoplasms (MPN) are associated with a variety of symptoms that severely impact patients’ quality of life and ability to perform daily activities. Recent studies showed differences in the perception of physician- versus patient-reported
Reiter, Andreas, Manz, Kirsi, Heidel, Florian H., Döhner, Konstanze, Lipke, Jörg, Isfort, Susanne, Schlag, Rudolf, Klausmann, Martine, Schulz, Holger, Al-Ali, Haifa Kathrin, Kricheldorf, Kim, Beutel, Gernot, Crodel, Carl, Koschmieder, Steffen, Brümmendorf, Tim H., Stegelmann, Frank, Hochhaus, Andreas, Grießhammer, Martin, Göthert, Joachim Rudolf, Hoffmann, Wolfgang, Becker, Heiko   +20 more
core   +2 more sources

Targeted therapies for myeloproliferative neoplasms

Biomarker Research, 2019
The discovery of JAK2V617F and the demonstration that BCR-ABL-negative myeloproliferative neoplasms (MPNs) are driven by abnormal JAK2 activation have led to advances in diagnostic algorithms, prognosis and ultimately also treatment strategies. The JAK 1/
Bing Li, Raajit K. Rampal, Zhijian Xiao
doaj   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Model for the proposed BM mediated protection of MPN cells.

, 2015
In vitro, MPN cells (SET-2, HEL, UKE-1 cell lines and MPN patient BM-derived Lin-CD34+ cells) are killed once exposed to chemotherapeutic agents, like Vorinostat and Ruxolitinib, as a result of the inhibition of HDAC enzymes and JAK2V617F mutant protein ...
António M. Almeida (832215), Hélio Belo (104574), João T. Barata (263904), Bruno A. Cardoso (104572)   +3 more
core   +1 more source

NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML [PDF]

, 2020
Overlapping myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders with features of myelodysplasia and myeloproliferation.
Breese, Marcus R., Sweet-Cordero, E. Alejandro, Stanley G. Leung, Dvorak, Christopher C, Marcus R. Breese, Young, Elizabeth P., Julia Chu, Astrid Behnert, Maria Maruffi, Elliot Stieglitz, Chu, Julia, Alex G. Lee, Inge Behroozfard, Leung, Stanley G., Leung, Stanley G, Young, Elizabeth P, E. Alejandro Sweet-Cordero, Behroozfard, Inge, Christopher C. Dvorak, Lee, Alex G, Maruffi, Maria, Elizabeth P. Young, Stieglitz, Elliot, Lee, Alex G., Breese, Marcus R, Sweet-Cordero, E Alejandro, Dvorak, Christopher C., Behnert, Astrid   +27 more
core   +1 more source