Results 41 to 50 of about 69,250 (228)

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai   +13 more
wiley   +1 more source

A Duality Result for Moduli Spaces of Semistable Sheaves Supported on Projective Curves

open access: yes, 2010
We show that the moduli space M(r,c) of semistable sheaves on n-dimensional projective space with support of dimension one, with multiplicity r and with Euler characteristic c is isomorphic to M(r,-c).Comment: In the second version we rewrite the proofs ...
Maican, Mario
core   +1 more source

Bacterial community profiles and Vibrio parahaemolyticus abundance in individual oysters and their association with estuarine ecology [PDF]

open access: yes, 2017
Oysters naturally harbor the human gastric pathogen Vibrio parahaemolyticus, but the nature of this association is unknown. Because microbial interactions could influence the accumulation of V. parahaemolyticus in oysters, we investigated the composition
Cooper, Vaughn S.   +4 more
core   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Two variable deformations of the Chebyshev measure

open access: yes, 2006
We construct one and two parameter deformations of the two dimensional Chebyshev polynomials with simple recurrence coefficients, following the algorithm in [3].
Geronimo, Jeffrey S., Iliev, Plamen
core   +2 more sources

Large‐Scale Quantitative Morphometry of Platelet α‐Granules via SIM Super‐Resolution Microscopy for Cancer Liquid Biopsy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Blood‐based liquid biopsies hold transformative potential for non‐invasive cancer management, but current approaches relying on rare circulating tumor components limit their broad clinical utility. Platelets, abundant in blood and mediating diverse cancer‐associated responses, represent a compelling yet largely unexplored alternative.
Yan Ma   +28 more
wiley   +1 more source

Tamarind (Tamarindus indica L.) parkland mycorrhizal potential within three agro-ecological zones of Senegal [PDF]

open access: yes, 2010
Introduction. Tamarind (Tamarindus indica L.) belongs to the Fabaceae family; it is a multipurpose tree with slow growth. In order to help improve its growth and development, we assessed mycorrhizal diversity of tamarind parklands in Senegal.
Bourou, Sali   +4 more
core   +2 more sources

Real‐World Outcomes of FLAG‐Ida Regimen in 1079 Adult Patients With First Relapsed/Refractory AML: A PETHEMA Study

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena   +49 more
wiley   +1 more source

Disease Remission: A Scoping Review With Thematic Analysis of the Scientific Literature With Implications for Chronic Rhinosinusitis

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Remission, a term used to describe a goal of treatment for some chronic diseases, has recently been proposed for chronic rhinosinusitis (CRS). However, it is unclear what remission means for CRS and why it should serve as a goal in the present‐day treatment of CRS.
Nikhil Parail   +7 more
wiley   +1 more source

Many roads lead to MPN

open access: yesBlood, 2014
In this issue of Blood, Lundberg et al correlate the presence of known mutations in patients with myeloproliferative neoplasms (MPNs) with clinical outcome, thereby proposing a molecular risk stratification.
openaire   +4 more sources

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