Results 121 to 130 of about 82,070 (285)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Deep learning in MR-guided radiotherapy

, 2021
Les pratiques modernes en radiothérapie améliorent considérablement le succès des traitements tout en épargnant autant que possible les tissus sains. Cela se fait en réduisant constamment les incertitudes en amont du traitement. La planification du traitement débute avec une acquisition 3D de la géométrie du patient.
openaire   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

A simplified online adaptive workflow for long-course magnetic resonance-guided radiotherapy in esophageal cancer

Physics and Imaging in Radiation Oncology
Background and Purpose: Online adaptive magnetic resonance-guided radiotherapy (MRgRT) enables high-precision radiotherapy for esophageal cancer patients but is less feasible due to long on-table times in combination with long-course treatment.
Koen M. Kuijer, Roel Bouwmans, Lando S. Bosma, Stella Mook, Gert J. Meijer   +4 more
doaj   +1 more source

An end-to-end test for MR-guided online adaptive radiotherapy

Physics in Medicine & Biology, 2020
In the evolving field of adaptive MR guided radiotherapy, the need for dedicated procedures for acceptance and quality assurance is increasing. Research has been devoted to MR compatible dosimeters and phantoms, but to date no end-to-end test has been presented that covers an MRgRT workflow.
Hoffmans, Daan, Niebuhr, Nina, Bohoudi, Omar, Pfaffenberger, Asja, Palacios, Miguel   +4 more
openaire   +3 more sources

Efficacy of Multimodal Work‐Up of Head and Neck Squamous Cell Carcinoma Lymph Node Metastasis of Unknown Primary

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) often presents with cervical lymph node metastasis, with 1%–4% of cases presenting as cancer of unknown primary (CUP). CUP poses diagnostic and therapeutic challenges and is linked to poorer survival outcomes.
Robin W. Jansen, Roland M. Martens, Obaida Abdulrahman, Laura Peferoen, C. René Leemans, Gerben J. C. Zwezerijnen, Jan‐Jaap Hendrickx, Pim de Graaf   +7 more
wiley   +1 more source

How Would You Treat? A Case‐Vignette Study of Provider Treatment Preferences in Human Papillomavirus‐Mediated Oropharyngeal Cancer

Head &Neck, EarlyView.
ABSTRACT Background Current guidelines recommend surgical resection, definitive radiotherapy (RT), or concurrent chemoradiotherapy (CRT) for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (OPSCC). This study aimed to provide insight into practice patterns of providers who treat HPV‐associated OPSCC.
Sindhura Sridhar, Michael R. Papazian, Michael C. Topf   +2 more
wiley   +1 more source

Robustness of radiomics features on 0.35 T magnetic resonance imaging for magnetic resonance-guided radiotherapy

Physics and Imaging in Radiation Oncology
Background and purpose: MR-guided radiotherapy adds the precision of magnetic resonance imaging (MRI) to the therapeutic benefits of a linear accelerator.
Morgan Michalet, Gladis Valenzuela, Pierre Debuire, Olivier Riou, David Azria, Stéphanie Nougaret, Marion Tardieu   +6 more
doaj   +1 more source

Medical image computing and computer-aided medical interventions applied to soft tissues. Work in progress in urology

, 2006
Until recently, Computer-Aided Medical Interventions (CAMI) and Medical Robotics have focused on rigid and non deformable anatomical structures. Nowadays, special attention is paid to soft tissues, raising complex issues due to their mobility and ...
Bart, Stéphane, Baumann, Michael, Berkelman, Peter, Bolla, Michel, Chartier-Kastler, Emmanuel, Cinquin, Philippe, Daanen, Vincent, Descotes, Jean-Luc, Dusserre, Andrée, Giraud, Jean-Yves, Leroy, Antoine, Long, Jean-Alexandre, Marchal, Maud, Moalic, Ronan, Mozer, Pierre, Payan, Yohan, Promayon, Emmanuel, Troccaz, Jocelyne, Voros, Sandrine   +18 more
core   +1 more source

MR-guided radiotherapy for patients with lymph node oligometastases

, 2022
Magnetic resonance imaging (MRI) provides superior soft tissue contrast compared with computed tomography (CT) imaging. Image guidance during radiotherapy treatments is of pivotal importance to ensure accurate deposition of the radiation dose at the clinical target.
openaire   +2 more sources