Results 41 to 50 of about 301,410 (296)

Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers

, 2017
Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at enhancers has been proposed to mark active enhancers and as such has been utilized to ...
Taylor, Martin; id_orcid, School of Population Health Sciences, Young, Robert; id_orcid, Medical Research Council, MRC Human Genetics Unit, Young, Robert, Taylor, Martin   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

High genetic stability of dengue virus propagated in MRC-5 cells as compared to the virus propagated in vero cells. [PDF]

PLoS ONE, 2008
This work investigated the replication kinetics of the four dengue virus serotypes (DEN-1 to DEN-4), including dengue virus type 4 (DEN-4) recovered from an infectious cDNA clone, in Vero cells and in MRC-5 cells grown on Cytodex 1 microcarriers.
Chia-Chyi Liu, Shiang-Chi Lee, Michael Butler, Suh-Chin Wu   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Using 4+ to grade near-normal muscle strength does not improve agreement

Chiropractic & Manual Therapies, 2017
Background Manual assessment of muscle strength is often graded using the ordinal Medical Research Council (MRC) scale. The scale has a number of inherent weaknesses, including poorly defined limits between grades ‘4’ and ‘5’ and very large differences ...
Søren O’Neill, Sofie Louise Thomsen Jaszczak, Anne Katrine Søndergaard Steffensen, Birgit Debrabant   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fiabilidad y validez de la escala MRC de 4 puntos para el diagnóstico de debilidad adquirida en la unidad de cuidados intensivos: estudio prospectivo

Argentinian Journal of Respiratory and Physical Therapy
Objetivo: Determinar la fiabilidad y validez de la nueva escala de 4 puntos del Consejo de Investigación Médica (MRC-4), en comparación con la escala tradicional de 6 puntos (MRC-6) y la dinamometría de fuerza de prensión manual (HGD, por sus siglas en ...
Joaquín Martinez Guarnieri, Martín Gutiérrez Clas, María Florencia Bilbao, Constanza Milagros Verteramo, Franco Tedesco, Dolores Maturo, Brandon Asem, Mariana Alejandra Caratti, Diego Rafael Garcia Rosello, Ariel Pattone, Florencia Romina Pintos, Malena Grassino, Cristian Alfredo Colinas, Julieta Ormazabal   +13 more
doaj   +1 more source

R-Trans: RNN Transformer Network for Chinese Machine Reading Comprehension

IEEE Access, 2019
Machine reading comprehension (MRC) has gained increasingly wide attention over the past few years. A variety of benchmark datasets have been released, which triggers the development of quite a few MRC approaches based on deep learning techniques ...
Shanshan Liu, Sheng Zhang, Xin Zhang, Hui Wang   +3 more
doaj   +1 more source

Clinical Characteristics and Optimal Therapy of Acute Myeloid Leukemia with Myelodysplasia-Related Changes: A Retrospective Analysis of a Cohort of Chinese Patients

Turkish Journal of Hematology, 2021
Objective: This study aimed to investigate the clinical characteristics of acute myeloid leukemia with myelodysplasia-related changes (AMLMRC) according to the 2016 World Health Organization classification and the preferred therapy for patients with AML ...
Lei Wang, Xiaoxia Chu, Jingyao Wang, Licai An, Yinghui Liu, Li Li, Junqing Xu   +6 more
doaj   +1 more source

Efficient Machine Reading Comprehension for Health Care Applications: Algorithm Development and Validation of a Context Extraction Approach

JMIR Formative Research
BackgroundExtractive methods for machine reading comprehension (MRC) tasks have achieved comparable or better accuracy than human performance on benchmark data sets.
Duy-Anh Nguyen, Minyi Li, Gavin Lambert, Ryszard Kowalczyk, Rachael McDonald, Quoc Bao Vo   +5 more
doaj   +1 more source