Results 31 to 40 of about 301,410 (296)
Analysis of MRC-funded non-academic impacts submitted to REF2021
, 2023 This report provides a selection of research impacts submitted by UK higher education institutions (HEIs) to the 2021 REF assessment that had a connection to the Medical Research Council (MRC) investments.
Samarasinghe, S., Pitrolino, K.
core
Human genetic variation and disease [PDF]
, 2016 The data forms part of the Resource pack Human genetic variation and disease, which is a real data resource to allow students to explore genetic and phenotypic data as part of their Scottish Qualifications Authority Nat5 or Higher Biology Assignment ...
Kerr, Shona +3 more
core +1 more source
Asian Journal of Surgery, 2004 Magnetic resonance cholangiography (MRC) is a non-invasive imaging modality that has become widely available. In the short time since its introduction, MRC has been shown to possess excellent accuracy for the diagnosis of various biliary pathologies ...
Terrence H. Liu, Claude H. Organ, Jr.
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
MRC Available CMR-derived phenotypes
, 2022 Available CMR-derived phenotypes for MRC ...
Nay Aung (11874419)
core +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Clinical Ophthalmology, 2022 Mohamed Elkadim, Mohamed H Nasef, Ahmed Roshdy Alagorie, Waleed A Allam Department of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, EgyptCorrespondence: Mohamed Elkadim, Department of Ophthalmology, Faculty of Medicine, Tanta University ...
Elkadim M +3 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Frontiers in NeurologyBackgroundLennox–Gastaut syndrome (LGS), a severe developmental epileptic encephalopathy, has various underlying causes. Mitochondrial respiratory chain complex I (MRC I) deficiency is an important cause of metabolic disorders such as mitochondrial ...
Ji-Hoon Na, Young-Mock Lee
doaj +1 more source