Results 1 to 10 of about 97,528 (241)

L-EGCG-Mn nanoparticles as a pH-sensitive MRI contrast agent [PDF]

Drug Delivery, 2021
This study aimed to synthesize and characterize L-epigallocatechin gallate (EGCG) complexed Mn2+ nanoparticle (L-EGCG-Mn), a proof-of-concept pH-sensitive manganese core nanoparticle (NP), and compare its magnetic resonance (MR) properties with those of ...
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen, Zhiping Zhang   +8 more
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Liver-targeting MRI contrast agent based on galactose functionalized o-carboxymethyl chitosan [PDF]

Frontiers in Bioengineering and Biotechnology, 2023
Commercial gadolinium (Gd)-based contrast agents (GBCAs) play important role in clinical diagnostic of hepatocellular carcinoma, but their diagnostic efficacy remained improved.
Li Xu, Zhanying Ren, Zhanying Ren, Guolin Li, Danni Xu, Jiaqian Miao, Jingxuan Ju, Xuan Mo, Xianghui Wang, Hongping Deng, Min Xu   +10 more
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Nanosized T₁ MRI Contrast Agent Based on a Polyamidoamine as Multidentate Gd Ligand [PDF]

Molecules, 2021
A linear polyamidoamine (PAA) named BAC-EDDS, containing metal chelating repeat units composed of two tert-amines and four carboxylic groups, has been prepared by the aza-Michael polyaddition of ethylendiaminodisuccinic (EDDS) with 2,2-bis(acrylamido ...
Paolo Arosio, Davide Cicolari, Amedea Manfredi, Francesco Orsini, Alessandro Lascialfari, Elisabetta Ranucci, Paolo Ferruti, Daniela Maggioni   +7 more
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A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging [PDF]

Nature Communications, 2022
Magnetic resonance imaging (MRI) is a well-established non-invasive medical imaging technology. Here, to improve the performance of the technique, the authors describe the design of a pH-responsive T1-T2 dual-modal MRI contrast agent, showing enhanced ...
Hongwei Lu, An Chen, Xindan Zhang, Zixiang Wei, Rong Cao, Yi Zhu, Jingxiong Lu, Zhongling Wang, Leilei Tian   +8 more
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PEG-Coated MnZn Ferrite Nanoparticles with Hierarchical Structure as MRI Contrast Agent [PDF]

Nanomaterials, 2023
In this work, MnZn ferrite nanoparticles with hierarchical morphology were synthesized hydrothermally, and their surface characteristics were improved by the PEGylation process.
Sedigheh Cheraghali, Ghasem Dini, Isabella Caligiuri, Michele Back, Flavio Rizzolio   +4 more
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Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent [PDF]

Advanced Science
The potential applications of rare earth elements (REEs) in biomedical fields have been intensively investigated. Numerous studies have shown that doping biomaterials with REEs can enhance their properties.
Xingtong Pan, Menglong Hu, Likun Wu, Erfan Wei, Qiyue Zhu, Letian Lv, Xiuyun Xv, Xinyi Dong, Hao Liu, Yunsong Liu   +9 more
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Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
To discover novel multifunctional agents for the treatment of Parkinson’s disease, a series of 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives was designed, synthesized and evaluated.
Zhongcheng Cao, Xingyue Wang, Tianlong Zhang, Xianwu Fu, Fan Zhang, Jiang Zhu   +5 more
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A versatile genetic-encoded reporter for magnetic resonance imaging

Heliyon, 2023
It has been a long-cherished wish in biomedicine research to have an imaging tool to visualize gene expression, with good spatiotemporal resolution, in rodent and primate animals noninvasively and longitudinally.
Haiyang Yang, Zhengjiang Qian, Chunhua Liu, Changjun Tie, Aoling Cai, Jie Wang, Yao Xing, Jun Xia, Xiang Li   +8 more
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The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure

Scientific Reports, 2023
The leitmotifs of magnetic resonance imaging (MRI) contrast agent-induced complications range from acute kidney injury, symptoms associated with gadolinium exposure (SAGE)/gadolinium deposition disease, potentially fatal gadolinium encephalopathy, and ...
Joshua DeAguero, Tamara Howard, Donna Kusewitt, Adrian Brearley, Abdul-Mehdi Ali, James H. Degnan, Stephen Jett, John Watt, G. Patricia Escobar, Karol Dokladny, Brent Wagner   +10 more
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A Photocleavable Contrast Agent for Light-Responsive MRI

Pharmaceuticals, 2020
Thanks to its innocuousness and high spatiotemporal resolution, light is used in several established and emerging applications in biomedicine. Among them is the modulation of magnetic resonance imaging (MRI) contrast agents’ relaxivity with the aim to ...
Friederike Reeßing, Sèvrin E. M. Huijsse, Rudi A. J. O. Dierckx, Ben L. Feringa, Ronald J.H. Borra, Wiktor Szymański   +5 more
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