Results 31 to 40 of about 101,642 (212)

Design of a modular protein-based MRI contrast agent for targeted application. [PDF]

PLoS ONE, 2013
Magnetic resonance imaging (MRI) offers a non-radioactive alternative for the non-invasive detection of tumours. Low molecular weight MRI contrast agents currently in clinical use suffer either from a lack of specificity for tumour tissue or from low ...
Daniel Grum, Stefan Franke, Oliver Kraff, Dominik Heider, Alexander Schramm, Daniel Hoffmann, Peter Bayer   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Sensing intracellular calcium ions using a manganese-based MRI contrast agent

Nature Communications, 2019
There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring ...
Ali Barandov, Benjamin B. Bartelle, Catherine G. Williamson, Emily S. Loucks, Stephen J. Lippard, Alan Jasanoff   +5 more
doaj   +1 more source

Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure

BMC Cancer, 2012
Background High interstitial fluid pressure (IFP) in the primary tumor is associated with poor disease-free survival in locally advanced cervical carcinoma. A noninvasive assay is needed to identify cervical cancer patients with highly elevated tumor IFP
Hompland Tord, Ellingsen Christine, Rofstad Einar K   +2 more
doaj   +1 more source

New Class of Efficient T₂ Magnetic Resonance Imaging Contrast Agent: Carbon-Coated Paramagnetic Dysprosium Oxide Nanoparticles

Pharmaceuticals, 2020
Nanoparticles are considered potential candidates for a new class of magnetic resonance imaging (MRI) contrast agents. Negative MRI contrast agents require high magnetic moments.
Huan Yue, Ji Ae Park, Son Long Ho, Mohammad Yaseen Ahmad, Hyunsil Cha, Shuwen Liu, Tirusew Tegafaw, Shanti Marasini, Adibehalsadat Ghazanfari, Soyeon Kim, Kwon Seok Chae, Yongmin Chang, Gang Ho Lee   +12 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Nanoscale Research Letters, 2010
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a ...
Kim Hyo Jeong, Lee Ha-Young, Seong Hasoo, Shin Byung Cheol, Yuk Soon Hong, Cho Sun Hang, Kwak Byung-Kook, Jeong Sang Young, Hwang Sung-Joo   +8 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Amyloid Plaque Imaging with a Targeted MRI Contrast Agent in a Transgenic Mouse Model of Alzheimer’s Disease

International Journal of Nanomedicine, 2022
Yongjie Xiong,1 Yi Qu,1 Zhe Min,1 Jun Wu,2 Suming Zhang,1 Zheng Xue1 1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China; 2Department of ...
Xiong Y, Qu Y, Min Z, Wu J, Zhang S, Xue Z   +5 more
doaj  

Crystal structure of diethyl 3,3′-[(2,4-dichlorophenyl)methylidene]bis(1H-indole-2-carboxylate)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C29H24Cl2N2O4, the mean planes of the two indole ring systems (r.m.s. deviations = 0.1249 and 0.0075 Å) are approximately perpendicular to one another, with a dihedral angle of 80.9 (5)° between them.
Yu-Long Li, Hong-Shun Sun, Hong Jiang, Yu-Liang Chen, Yang-Feng Chen   +4 more
doaj   +1 more source