Results 141 to 150 of about 101,642 (212)

Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions. [PDF]

Angew Chem Int Ed Engl, 2021
Wang G, Angelovski G.
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Gadopiclenol: A q = 2 Gadolinium-Based MRI Contrast Agent Combining High Stability and Efficacy. [PDF]

Invest Radiol
Maimouni I, Henoumont C, De Goltstein MC, Mayer JF, Dehimi A, Boubeguira Y, Kattenbeck C, Maas TJ, Decout N, Strzeminska I, Bazin G, Medina C, Factor C, Rousseaux O, Karst U, Laurent S, Catoen S.   +16 more
europepmc   +1 more source

Holmium(III) Single-Ion Magnet for Cryomagnetic Refrigeration Based on an MRI Contrast Agent Derivative. [PDF]

Inorg Chem, 2021
Rodríguez-Barea B, Mayans J, Rabelo R, Sanchis-Perucho A, Moliner N, Martínez-Lillo J, Julve M, Lloret F, Ruiz-García R, Cano J.   +9 more
europepmc   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Interaction of MRI Contrast Agent [Gd(DOTA)]^- with Lipid Membranes: A Molecular Dynamics Study. [PDF]

Inorg Chem
Oliveira AC, Filipe HAL, Geraldes CFGC, Voth GA, Moreno MJ, Loura LMS.   +5 more
europepmc   +1 more source

Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study. [PDF]

Nanomaterials (Basel), 2021
Nan X, Lai W, Li D, Tian J, Hu Z, Fang Q.   +5 more
europepmc   +1 more source

Asymmetrically Coordinated Dual‐Atom Manganese Contrast Agents Enabling High‐Efficiency T1 Enhanced MRI for Precise Tumor Visualization

Advanced Science, EarlyView.
A novel dual‐atom manganese MRI contrast agent (Mn‐BN) with a unique asymmetric coordination geometry provided a promising platform for sensitive and specific tumor imaging. In mice model, Mn‐BN nanoparticles precisely functioned as both a primary tumor‐specific enhancer in subcutaneous models and a hepatocyte‐specific agent in liver metastases models ...
Ding Yang, Qing‐Yang Li, Jianli Liang, Gengyou Li, Nan Sun, Qianqian Song, Haitao Zhu, Xiaoting Li, Zechuan Li, Jiankai Dong, Weisheng Guo, Yafang Xiao, Chun‐Sing Lee, Ying‐Shi Sun   +13 more
wiley   +1 more source

Pharmacokinetics and Tolerability of the Cancer-Targeting MRI Contrast Agent MT218 in Healthy Males. [PDF]

Invest Radiol
Li Y, Apseloff G, Tweedle MF, Gao S, Henry E, Lu ZR.   +5 more
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source