Results 11 to 20 of about 77,587 (260)

Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

Communications Biology, 2022
CD102 is an enriched biomarker for long-lived plasma cells in non-human primates (NHPs) and is conserved across NHPs, humans, and mice.
Ryan P. Staupe, Kenneth E. Lodge, Nithya Thambi, David Toole, Alex M. Tamburino, Dan Chang, Bonnie J. Howell, Daria J. Hazuda, Kalpit A. Vora, Nicole L. Sullivan   +9 more
doaj   +1 more source

Renal Lesions in MRL Mice [PDF]

Veterinary Pathology, 1982
Female MRL-Mp- lpr/ lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG and complement component 3 (C3) barely were detectable.
G J, Kolaja, P E, Fast
openaire   +2 more sources

Antibody enhanced HPLC for serotype-specific quantitation of polysaccharides in pneumococcal conjugate vaccine

npj Vaccines, 2023
Bacterial infection remains as one of the major healthcare issues, despite significant scientific and medical progress in this field. Infection by Streptococcus Pneumoniae (S. Pneumoniae) can cause pneumonia and other serious infectious diseases, such as
James Z. Deng, Nathan Kuster, Ashley Drumheller, Mingxiang Lin, Frances Ansbro, Milica Grozdanovic, Rachelle Samuel, Ping Zhuang   +7 more
doaj   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J., Huang, F.P., Liew, F.Y., Lindop, G., Stott, D.I.   +4 more
core   +3 more sources

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +2 more sources

SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

Frontiers in Oncology, 2022
IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-
Tze Guan Tan, Yulia Zybina, Cooper McKenna, Aleksandra Olow, Subhadra Jayaraman Rukmini, Michael Thomas Wong, Svetlana Sadekova, Alissa Chackerian, David Bauché   +8 more
doaj   +1 more source

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]

, 2015
Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M., Harnett, W., Pineda, M. A., Rodgers, D. T., Suckling, C. J.   +4 more
core   +1 more source

Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Neurobiology of Disease, 2021
TDP-43 pathology is a hallmark of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Namely, both diseases feature aggregated and phosphorylated TDP-43 containing inclusions in the cytoplasm and a loss of nuclear TDP-43 in ...
Yuan Tian, Yi Wang, Angela M. Jablonski, Yinghui Hu, Jonathan A. Sugam, Markus Koglin, Shawn J. Stachel, Heather Zhou, Jason M. Uslaner, Sophie Parmentier-Batteur   +9 more
doaj   +1 more source

B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus [PDF]

, 2016
Background: Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical manifestations in human lupus. However, its mechanisms are not fully understood.
A Ahuja, A Altman, A Fanouriakis, A Ivanova, A Katzav, A Unterman, A Zameer, A Zameer, AD Stock, AE Gharavi, AM Khalil, Ariel Stock, B Sakic, B Sakic, B Sakic, C Choi, C Gemma, C Kowal, C Kowal, Chaim Putterman, D Perry, DA Ballok, DA Ballok, DG Alleva, DK Dunn-Walters, G Steup-Beekman, GK Bertsias, H Fragoso-Loyo, H Fragoso-Loyo, H Okamoto, H Suzuki, Haowei Wang, HX Gao, I Marin, J Wen, J Wen, Jessica Doerner, JF Cryan, JG Hanly, Jing Wen, JJ Alexander, JJ Alexander, LL Teichmann, M Bravo-Zehnder, M Gulinello, M Gulinello, M Hughes, M Stanojcic, M Tokunaga, Maria Gullinello, Mark J. Shlomchik, MD Bauman, NC Derecki, NJ Abbott, O Chan, OT Chan, PD Cole, RN Hiramoto, S Kivity, S Mandlekar, S Najjar, S Sciascia, Samantha Chalmers, SL Eko, T Cobo-Ibanez, T Gono, Y Arinuma, Y Li, Y Li, Y Sherer, Y Ziv   +70 more
core   +3 more sources