Results 11 to 20 of about 30,943 (238)

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F.Y., Feng, G.J., Lindop, G., Huang, F.P., Stott, D.I.   +4 more
core   +9 more sources

Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates

Human Vaccines & Immunotherapeutics, 2017
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang, Daniel C. Freed, Fengsheng Li, Steve Meschino, Michael Prokop, Andrew Bett, Danilo Casimiro, Dai Wang, Tong-Ming Fu   +8 more
doaj   +1 more source

Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

AAPS Open, 2018
Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties ...
Maribel Beaumont, Daniela Tomazela, Douglas Hodges, Grigori Ermakov, Edward Hsieh, Isabel Figueroa, On-Yee So, Yaoli Song, Huiping Ma, Svetlana Antonenko, Wondwessen Mengesha, Yi Wei Zhang, Shuli Zhang, SuChun Hseih, Gulesi Ayanoglu, Xiaoyan Du, Eric Rimmer, Michael Judo, Franklin Vives, Jennifer H. Yearley, Christina Moon, Anthony Manibusan, Nick Knudsen, Andy Beck, Damien Bresson, Dennis Gately, Divas Neupane, Enrique Escandón   +27 more
doaj   +1 more source

Evaluation of Pesticide Residues in Vegetables from the Asir Region, Saudi Arabia

Molecules, 2020
This study’s aim was to determine the pesticide residues in 10 different vegetable commodities from the Asir region, Saudi Arabia. We evaluated 211 vegetable samples, collected from supermarkets between March 2018 and September 2018, for a total of
Mohamed F. A. Ramadan, Mohamed M. A. Abdel-Hamid, Montasser M. F. Altorgoman, Hamed A. AlGaramah, Mohammed A. Alawi, Ali A. Shati, Hoda A. Shweeta, Nasser S. Awwad   +7 more
doaj   +1 more source

Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Neurobiology of Disease, 2021
TDP-43 pathology is a hallmark of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Namely, both diseases feature aggregated and phosphorylated TDP-43 containing inclusions in the cytoplasm and a loss of nuclear TDP-43 in ...
Yuan Tian, Yi Wang, Angela M. Jablonski, Yinghui Hu, Jonathan A. Sugam, Markus Koglin, Shawn J. Stachel, Heather Zhou, Jason M. Uslaner, Sophie Parmentier-Batteur   +9 more
doaj   +1 more source

A novel approach to determine residual aldehyde content in conjugated polysaccharides with 3-methyl-2-benzothiazolinonehydrazon (MBTH) by colorimetric method, automation, and HP-SEC

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Polysaccharide activation by periodate oxidation to form aldehydes, followed by conjugation with proteins via reductive amination is a general procedure to make polysaccharide-protein conjugate vaccines.
Weidong Tong, Mingxiang Lin, Ping Zhuang, Bukuru Anaclet, Castle Cooper   +4 more
doaj   +1 more source

MRL and SuperFine+MRL: new supertree methods [PDF]

, 2012
Background Supertree methods combine trees on subsets of the full taxon set together to produce a tree on the entire set of taxa. Of the many supertree methods, the most popular is MRP (Matrix Representation with Parsimony), a method that operates by ...
Mirarab Siavash, Nguyen, Nam, Warnow Tandy, Nguyen Nam, Tandy Warnow, Warnow, Tandy, Nam Nguyen, Mirarab, Siavash, Siavash Mirarab   +8 more
core   +1 more source

Residues of Fluoroquinolone Antibiotics Induce Carbonylation and Reduce In Vitro Digestion of Sarcoplasmic and Myofibrillar Beef Proteins

Foods, 2020
Although the impact of oxidation on human health has been of growing interest, the oxidation of proteins, major component of meat, has received little attention.
Johana Márquez-Lázaro, Darío Méndez-Cuadro, Erika Rodríguez-Cavallo   +2 more
doaj   +1 more source

Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial

Critical Care, 2021
Background Ceftolozane/tazobactam is approved for treatment of hospital-acquired/ventilator-associated bacterial pneumonia (HABP/VABP) at double the dose approved for other infection sites.
Jean-François Timsit, Jennifer A. Huntington, Richard G. Wunderink, Nobuaki Shime, Marin H. Kollef, Ülo Kivistik, Martin Nováček, Álvaro Réa-Neto, Ignacio Martin-Loeches, Brian Yu, Erin H. Jensen, Joan R. Butterton, Dominik J. Wolf, Elizabeth G. Rhee, Christopher J. Bruno   +14 more
doaj   +1 more source

BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning

mAbs, 2022
Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil, Danny A. Bitton   +6 more
doaj   +1 more source