Results 11 to 20 of about 33,403 (259)

MRL and SuperFine+MRL: new supertree methods [PDF]

Algorithms for Molecular Biology, 2012
Abstract Background Supertree methods combine trees on subsets of the full taxon set together to produce a tree on the entire set of taxa. Of the many supertree methods, the most popular is MRP (Matrix Representation with Parsimony), a method that operates by first encoding the input set of source trees by a large ...
Nam-phuong Nguyen, Siavash Mirarab, Tandy J. Warnow   +2 more
openaire   +7 more sources

The superior healing capacity of MRL tendons is minimally influenced by the systemic environment of the MRL mouse

Scientific Reports, 2023
AbstractMurphy Roths Large mice (MRL) exhibit improved tendon healing and are often described as a “super-healer” strain. The underlying mechanisms that drive the superior healing response of MRL remain a controversial subject. We utilized a tendon transplantation model between MRL and “normal-healer” B6-mice to differentiate between the contribution ...
Borys Frankewycz, Rebecca Bell, Monideepa Chatterjee, Nelly Andarawis-Puri   +3 more
openaire   +4 more sources

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F.Y., Feng, G.J., Lindop, G., Huang, F.P., Stott, D.I.   +4 more
core   +9 more sources

Evaluation of Concordance between Radiation Therapists and Medical Physicists in MR-Guided Online Adaptive Planning. [PDF]

Precis Radiat Oncol
Magnetic resonance (MR)‐guided online adaptive radiotherapy requires skill in online adaptive treatment planning. This study demonstrated that radiation therapists, with appropriate training, can consistently produce high‐quality adaptive plans concordant with those created by medical physicists for treatment on a 1.5 Tesla MR‐Linac.
Birring E, Zhao Y, Lim TY, Mohammedsaid M, Hughes N, Tharp C, Tealer J, Lin R, Hassanzadeh C, Fuller CD, Yang J.   +10 more
europepmc   +2 more sources

Sjögren's syndrome in MRL/l and MRL/n mice [PDF]

Arthritis & Rheumatism, 1984
AbstractSix autoimmune murine models (MRL/l, MRL/n, NZB, NZB/NZW, PN, C57BL/6J‐lpr/lpr) were compared with normal control C57BL/6J and DBA/2 mice to determine if spontaneous autoimmune disease was associated with evidence of Sjögren's syndrome. Schirmer tests documented dry eyes in NZB/NZW and PN mice; other autoimmune strains and controls had normal ...
R W, Hoffman, M A, Alspaugh, K S, Waggie, J B, Durham, S E, Walker   +4 more
openaire   +2 more sources

Band Keratopathy in MRL/1 and MRL/n Mice [PDF]

Arthritis & Rheumatism, 1983
AbstractTo define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/1, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp‐Ipr/lpr, C57BL/6J‐lpr/lpr, and normal control strains.
Hoffman, R W, Yang, H K, Waggie, K S, Durham, J B, Burge, J R, Walker, S E   +5 more
openaire   +1 more source

Statement on MRLs for difluoroacetic acid (DFA). [PDF]

EFSA J
Abstract In accordance with Article 43 of Regulation (EC) No 396/2005, the European Commission requested EFSA to carry out a targeted review of the maximum residue levels (MRLs) for difluoroacetic acid (DFA), following the availability of data on DFA residue levels in commodities for which EU MRLs are based on Codex MRLs. EFSA identified the Codex MRLs
European Food Safety Authority (EFSA).
europepmc   +3 more sources

Renal Lesions in MRL Mice [PDF]

Veterinary Pathology, 1982
Female MRL-Mp- lpr/ lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG and complement component 3 (C 3
G J, Kolaja, P E, Fast
openaire   +2 more sources

SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

Frontiers in Oncology, 2022
IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-
Tze Guan Tan, Yulia Zybina, Cooper McKenna, Aleksandra Olow, Subhadra Jayaraman Rukmini, Michael Thomas Wong, Svetlana Sadekova, Alissa Chackerian, David Bauché   +8 more
doaj   +1 more source

Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

AAPS Open, 2018
Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties ...
Maribel Beaumont, Daniela Tomazela, Douglas Hodges, Grigori Ermakov, Edward Hsieh, Isabel Figueroa, On-Yee So, Yaoli Song, Huiping Ma, Svetlana Antonenko, Wondwessen Mengesha, Yi Wei Zhang, Shuli Zhang, SuChun Hseih, Gulesi Ayanoglu, Xiaoyan Du, Eric Rimmer, Michael Judo, Franklin Vives, Jennifer H. Yearley, Christina Moon, Anthony Manibusan, Nick Knudsen, Andy Beck, Damien Bresson, Dennis Gately, Divas Neupane, Enrique Escandón   +27 more
doaj   +1 more source