Results 21 to 30 of about 78,373 (263)
AAPS Open, 2018 Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties ...
Maribel Beaumont +27 more
doaj +1 more source
Critical Care, 2021 Background Ceftolozane/tazobactam is approved for treatment of hospital-acquired/ventilator-associated bacterial pneumonia (HABP/VABP) at double the dose approved for other infection sites.
Jean-François Timsit +14 more
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mAbs, 2022 Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda +6 more
doaj +1 more source
Foods, 2020 Although the impact of oxidation on human health has been of growing interest, the oxidation of proteins, major component of meat, has received little attention.
Johana Márquez-Lázaro +2 more
doaj +1 more source
Taste aversion learning in autoimmune MRL-lpr/lpr and Mrl +/+ mice
Brain, Behavior, and Immunity, 1987 Conditioned taste aversion to a neutral stimulus paired with an immunosuppressive drug (cyclophosphamide) was assessed in lupus-prone MRL-lpr/lpr and congenic control (MRL +/+) mice. The presence of lymphoproliferation in MRL-lpr/lpr mice was associated with poorer taste aversion learning and varied as a function of the dose of cyclophosphamide.
L J, Grota, R, Ader, N, Cohen
openaire +2 more sources
MRL: Learning to Mix with Attention and Convolutions
CoRR, 2022 In this paper, we present a new neural architectural block for the vision domain, named Mixing Regionally and Locally (MRL), developed with the aim of effectively and efficiently mixing the provided input features. We bifurcate the input feature mixing task as mixing at a regional and local scale. To achieve an efficient mix, we exploit the domain-wide
Shlok Mohta +2 more
openaire +2 more sources
Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils
Angewandte Chemie, EarlyView.Extended 1D phosphoryl “wires” stabilize in‐register amyloid tau fibrils, as demonstrated by multiple‐quantum spin‐counting NMR, TEM, and MD simulations, using fibrils of tau peptide jR2R3‐P301L (tau295–313) with phosphorylation at S305 or Y310. ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites ...
Lokeswara Rao Potnuru +8 more
wiley +2 more sources
Cost Effectiveness and Resource Allocation, 2021 Introduction In Hong Kong (HK), a single-cohort vaccination program for 10–12-year-old girls with the 9-valent human papillomavirus (HPV) vaccine (9vHPV; types 6/11/16/18/31/33/45/52/58) has been launched. This study assessed the public health impact and
Tak Hong Cheung +7 more
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The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J. +4 more
core +1 more source
PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants
Genome Biology, 2018 Functional characterization of the noncoding genome is essential for biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring), which predicts the ...
Corneliu A. Bodea +5 more
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