Results 41 to 50 of about 78,373 (263)

Exploratory analyses of clinical trial data used for health technology assessments: a retrospective evaluation

BMJ Open, 2022
Objectives To examine the validity and statistical limitations of exploratory analyses of clinical trial data commonly requested by agencies responsible for determining which medical products may be financed or reimbursed by a healthcare system.Design ...
Israel T Agaku, William Malbecq, Frank W Rockhold, Gary G Koch, Björn J Oddens, Ellen S Snyder, William WB Wang, Karen M Kaplan   +7 more
doaj   +1 more source

Heart regeneration in adult MRL mice [PDF]

Proceedings of the National Academy of Sciences, 2001
The reaction of cardiac tissue to acute injury involves interacting cascades of cellular and molecular responses that encompass inflammation, hormonal signaling, extracellular matrix remodeling, and compensatory adaptation of myocytes. Myocardial regeneration is observed in amphibians, whereas scar formation characterizes cardiac ventricular wound
J M, Leferovich, K, Bedelbaeva, S, Samulewicz, X M, Zhang, D, Zwas, E B, Lankford, E, Heber-Katz   +6 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]

Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M., Harnett, W., Pineda, M. A., Rodgers, D. T., Suckling, C. J.   +4 more
core   +1 more source

Pesticide MRLs as Trade Barriers: Evidence From Vietnam's Coffee and Rice Exporters

Agribusiness, EarlyView.
ABSTRACT As tariffs have declined globally through bilateral and regional trade agreements, food safety standards have emerged as significant determinants of agricultural trade flows. This study examines the impact of maximum residue limits (MRLs) for five pesticides—Azoxystrobin, Chlorpyrifos, Chlorantraniliprole, Clothianidin, and Cyhalothrin—on ...
Nhat Mai Nguyen, Hoa‐Thi‐Minh Nguyen, Kaliappa Kalirajan   +2 more
wiley   +1 more source

Hard Turning Performance Investigation of AISI D2 Steel under a Dual Nozzle MQL Environment

Lubricants, 2023
In recent years, hard turning has emerged as a burgeoning cutting technology for producing high-quality finishing of cylindrical-shaped hardened steel for a variety of industrial applications.
Rajashree Mallick, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source

B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus [PDF]

Background: Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical manifestations in human lupus. However, its mechanisms are not fully understood.
A Ahuja, A Altman, A Fanouriakis, A Ivanova, A Katzav, A Unterman, A Zameer, A Zameer, AD Stock, AE Gharavi, AM Khalil, Ariel Stock, B Sakic, B Sakic, B Sakic, C Choi, C Gemma, C Kowal, C Kowal, Chaim Putterman, D Perry, DA Ballok, DA Ballok, DG Alleva, DK Dunn-Walters, G Steup-Beekman, GK Bertsias, H Fragoso-Loyo, H Fragoso-Loyo, H Okamoto, H Suzuki, Haowei Wang, HX Gao, I Marin, J Wen, J Wen, Jessica Doerner, JF Cryan, JG Hanly, Jing Wen, JJ Alexander, JJ Alexander, LL Teichmann, M Bravo-Zehnder, M Gulinello, M Gulinello, M Hughes, M Stanojcic, M Tokunaga, Maria Gullinello, Mark J. Shlomchik, MD Bauman, NC Derecki, NJ Abbott, O Chan, OT Chan, PD Cole, RN Hiramoto, S Kivity, S Mandlekar, S Najjar, S Sciascia, Samantha Chalmers, SL Eko, T Cobo-Ibanez, T Gono, Y Arinuma, Y Li, Y Li, Y Sherer, Y Ziv   +70 more
core   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Single cell spatial profiling of FFPE splenic tissue from a humanized mouse model of HIV infection

Biomarker Research
Background Latency remains a major obstacle to finding a cure for HIV despite the availability of antiretroviral therapy. Due to virus dormancy, limited biomarkers are available to identify latent HIV-infected cells.
Guoxin Wu, Samuel H. Keller, Luca Sardo, Brian Magliaro, Paul Zuck, Carl J. Balibar, Claire Williams, Liuliu Pan, Mark Gregory, Kathy Ton, Jill Maxwell, Carol Cheney, Tom Rush, Bonnie J. Howell   +13 more
doaj   +1 more source