Results 41 to 50 of about 30,943 (238)

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill

Viruses
The HIV-1 envelope glycoprotein gp120 is prominently exposed on the surface of both HIV-1 virions and infected host cells, serving as a key marker of infection.
Guoxin Wu, Luca Sardo, Yuan Li, Steven D. Heron, BaoJen Shyong, Matthew Mazur, Daniel M. Gorman, Carl J. Balibar, Brian C. Magliaro, Craig Leach, Thomas Rush, Bonnie J. Howell   +11 more
doaj   +1 more source

Biostructural, biochemical and biophysical studies of mutant IDH1

Nature Communications
We report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform.
Mark A. McCoy, Jun Lu, F. Richard Miller, Stephen M. Soisson, Michael H. Lam, Christian Fischer   +5 more
doaj   +1 more source

Practical experiences with a syrup feeding study design based on a new MRL guideline SANTE11956/2016 rev.9 (2018)

Julius-Kühn-Archiv, 2020
A new study design, according to the guideline SANTE11956/2016 rev:9 (2018), was established to determine the maximum residue level (MRL) of plant protection products in honey.
Cohen, Yotam, Berger, Christian, Gonsior, Gundula, Knäbe, Silvio   +3 more
doaj   +1 more source

The superhealing MRL background improves muscular dystrophy [PDF]

, 2012
Background Mice from the MRL or “superhealing” strain have enhanced repair after acute injury to the skin, cornea, and heart. We now tested an admixture of the MRL genome and found that it altered the course of muscle pathology and cardiac function in a ...
Michele Hadhazy, Elizabeth M McNally, Swaggart Kayleigh A, Heydemann Ahlke, Kim Gene H, Kayleigh Swaggart, Holley-Cuthrell Jenan, Gene H Kim, Jenan Holley-Cuthrell, Ahlke Heydemann, Hadhazy Michele, McNally Elizabeth M   +11 more
core   +1 more source

Hard Turning Performance Investigation of AISI D2 Steel under a Dual Nozzle MQL Environment

Lubricants, 2023
In recent years, hard turning has emerged as a burgeoning cutting technology for producing high-quality finishing of cylindrical-shaped hardened steel for a variety of industrial applications.
Rajashree Mallick, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

Nature Communications
WRN helicase is an established synthetic lethal target for inhibition in the treatment of microsatellite instability-high (MSI-H) and mismatch repair deficient (MMRd) cancers.
Rachel L. Palte, Mihir Mandal, Justyna Sikorska, Artjohn B. Villafania, Meredith M. Rickard, Robert J. Bauer, Alexei V. Buevich, Xiaomei Chai, Jiafang He, Zahid Hussain, Markus Koglin, Hannah B. MacDonald, My S. Mansueto, Klaus Maskos, Joey L. Methot, Jaclyn Robustelli, Aileen Soriano, Marcel J. Tauchert, Sriram Tyagarajan, Minjia Zhang, Daniel J. Klein, Jacqueline D. Hicks, David G. McLaren, Sandra B. Gabelli, Daniel F. Wyss   +24 more
doaj   +1 more source

WASPAS Based Multi Response Optimization in Hard Turning of AISI 52100 Steel under ZnO Nanofluid Assisted Dual Nozzle Pulse-MQL Environment

Applied Sciences, 2023
Hard turning is an emerging machining technology that evolved as a substitute for grinding in the production of precision parts from hardened steel. It offers advantages such as reduced cycle times, lower costs, and environmental benefits over grinding ...
Saswat Khatai, Ramanuj Kumar, Amlana Panda, Ashok Kumar Sahoo   +3 more
doaj   +1 more source