Results 61 to 70 of about 77,587 (260)
Arthritis &Rheumatology, EarlyView.Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu +12 more
wiley +1 more source
Communications Biology, 2021 Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism.
Samuel Furse +6 more
doaj +1 more source
Frontiers in Endocrinology, 2022 AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai +6 more
doaj +1 more source
A panchromatic view of the bulge globular cluster NGC 6569 [PDF]
, 2019 We used high-resolution optical HST/WFC3 and multi-conjugate adaptive optics assisted GEMINI GeMS/GSAOI observations in the near-infrared to investigate the physical properties of the globular cluster NGC 6569 in the Galactic bulge.
Bellini, A. +14 more
core +2 more sources
Sequential study of vasculitis in MRL mice [PDF]
Laboratory Animals, 1987 The frequency, age of onset and organ distribution of spontaneously occurring vasculitis was examined in a sequential study with 170 MRL mice of both substrains. Necrotizing vasculitis was seen in 55·8% of MRL/Mp-lpr/lpr mice studied, beginning at the age of 3 months. The kidney and urinary bladder were most frequently involved.
M, Hewicker, G, Trautwein
openaire +2 more sources
Arthritis &Rheumatology, Accepted Article.Objectives The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in non‐lymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source
Biostructural, biochemical and biophysical studies of mutant IDH1
Nature CommunicationsWe report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform.
Mark A. McCoy +5 more
doaj +1 more source
npj Vaccines, 2021 Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using immune response ...
Julie Dudášová +8 more
doaj +1 more source
Fractal geometry of nature (bone) may inspire medical devices shape [PDF]
, 2010 Medical devices, as orthopaedics prostheses and dental implants, have been designed over years on the strength of mechanical, clinical and biological indications.
Matteo Sartori, Salvatore Longoni
core +1 more source
On the Zitterbewegung Transient Regime in a Coarse-Grained Space-Time [PDF]
, 2015 In the present contribution, by studying a fractional version of Dirac's equation for the electron, we show that the phenomenon of Zitterbewegung in a coarse-grained medium exhibits a transient oscillatory behavior, rather than a purely oscillatory ...
Helayël-Neto, José Abdalla +1 more
core +2 more sources