Results 61 to 70 of about 78,373 (263)

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

Nature Communications
WRN helicase is an established synthetic lethal target for inhibition in the treatment of microsatellite instability-high (MSI-H) and mismatch repair deficient (MMRd) cancers.
Rachel L. Palte, Mihir Mandal, Justyna Sikorska, Artjohn B. Villafania, Meredith M. Rickard, Robert J. Bauer, Alexei V. Buevich, Xiaomei Chai, Jiafang He, Zahid Hussain, Markus Koglin, Hannah B. MacDonald, My S. Mansueto, Klaus Maskos, Joey L. Methot, Jaclyn Robustelli, Aileen Soriano, Marcel J. Tauchert, Sriram Tyagarajan, Minjia Zhang, Daniel J. Klein, Jacqueline D. Hicks, David G. McLaren, Sandra B. Gabelli, Daniel F. Wyss   +24 more
doaj   +1 more source

Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

Communications Biology, 2021
Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism.
Samuel Furse, Adam J. Watkins, Nima Hojat, James Smith, Huw E. L. Williams, Davide Chiarugi, Albert Koulman   +6 more
doaj   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Luckow, Bruno, Mack, Matthias, Schlöndorff, Detlef, Vielhauer, Volker   +5 more
core   +1 more source

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Voluntary consumption of cyclophosphamide by Mrl mice

Brain, Behavior, and Immunity, 1989
Fluid-deprived, lupus-prone Mrl-lpr/lpr and congenic Mrl +/+ mice were provided with a single drinking bottle containing varying concentrations of cyclophosphamide (CY) dissolved in chocolate milk. Eighteen- and 20-week-old Mrl-lpr/lpr males with manifest symptoms of autoimmune disease voluntarily consumed more of the CY solution than Mrl +/+ mice of ...
L J, Grota, T R, Schachtman, J A, Moynihan, N, Cohen, R, Ader   +4 more
openaire   +2 more sources

Hyperparameter-free losses for model-based monocular reconstruction [PDF]

This work proposes novel hyperparameter-free losses for single view 3D reconstruction with morphable models (3DMM). We dispense with the hyperparameters used in other works by exploiting geometry, so that the shape of the object and the camera pose are ...
Batard, Thomas, Giró Nieto, Xavier, Ramon Maldonado, Eduard, Ruiz, Guillermo   +3 more
core   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Requests for malaria prevention advice to Public Health England, Malaria Reference Laboratory: a retrospective observational study.

BACKGROUND: The Malaria Reference Laboratory (MRL) provides a specialist advisory service for complex queries from healthcare professionals. This study was conducted to examine the types of queries that general practitioners and nurses ask around malaria
Blaze, Marie, Chiodini, Peter L, Godbole, Gauri, Smith, Valerie, Whitty, Christopher JM   +4 more
core   +1 more source