Results 61 to 70 of about 33,403 (259)

Simultaneous Detection of Steroid Esters and Multi‐Class Substances in Dried Blood Spots by LC‐HRMS/MS From a Single Spot for Human Doping Control

Drug Testing and Analysis, EarlyView.
A validated LC‐HRMS/MS method enabled, for the first time, the comprehensive detection of steroid esters and multi‐class menu substances from a single dried blood spot. Following extraction, the resulting extract is split into two aliquots, reducing sample consumption and simplifying the analytical workflow.
Panagiotis Sakellariou, Andreas Thomas, Sebastian Marcel Schröder, Jasmin Thelen, Mario Thevis   +4 more
wiley   +1 more source

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors

Nature Communications
WRN helicase is an established synthetic lethal target for inhibition in the treatment of microsatellite instability-high (MSI-H) and mismatch repair deficient (MMRd) cancers.
Rachel L. Palte, Mihir Mandal, Justyna Sikorska, Artjohn B. Villafania, Meredith M. Rickard, Robert J. Bauer, Alexei V. Buevich, Xiaomei Chai, Jiafang He, Zahid Hussain, Markus Koglin, Hannah B. MacDonald, My S. Mansueto, Klaus Maskos, Joey L. Methot, Jaclyn Robustelli, Aileen Soriano, Marcel J. Tauchert, Sriram Tyagarajan, Minjia Zhang, Daniel J. Klein, Jacqueline D. Hicks, David G. McLaren, Sandra B. Gabelli, Daniel F. Wyss   +24 more
doaj   +1 more source

Detection of Lower Molecular Mass Peptides, Steroid Esters, and Multi‐Class Substances in a Single Dried Blood Spot for Comprehensive Initial Testing in Doping Control

Drug Testing and Analysis, EarlyView.
A validated LC‐HRMS/MS method enabled, for the first time, the simultaneous detection of lower molecular mass peptides, steroid esters, and multi‐class menu substances from a single dried blood spot, maximizing analytical coverage while minimizing sample consumption through post‐extraction splitting into two aliquots.
Panagiotis Sakellariou, Andreas Thomas, Jasmin Thelen, Mario Thevis   +3 more
wiley   +1 more source

Heart regeneration in adult MRL mice [PDF]

Proceedings of the National Academy of Sciences, 2001
The reaction of cardiac tissue to acute injury involves interacting cascades of cellular and molecular responses that encompass inflammation, hormonal signaling, extracellular matrix remodeling, and compensatory adaptation of myocytes. Myocardial regeneration is observed in amphibians, whereas scar formation characterizes cardiac ventricular wound
J M, Leferovich, K, Bedelbaeva, S, Samulewicz, X M, Zhang, D, Zwas, E B, Lankford, E, Heber-Katz   +6 more
openaire   +2 more sources

Chemistry Underlying the Behavior of Food and Agricultural Components During Industrial Manufacturing Processes and Its Implications in Quality Assurance, Food Quality, and Food Safety Management: A Systematic Review

Food Safety and Health, EarlyView.
Industrial manufacturing processes have transformative effects on the components of food matrix. These transformations in food matrix and components have direct implications for quality assurance (QA), food quality (e.g., nutritional profile and texture), and food safety management (e.g., pathogen control and toxin mitigation). ABSTRACT This systematic
Chinaza Godswill Awuchi
wiley   +1 more source

A method to estimate probability of disease and vaccine efficacy from clinical trial immunogenicity data

npj Vaccines, 2021
Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using immune response ...
Julie Dudášová, Regina Laube, Chandni Valiathan, Matthew C. Wiener, Ferdous Gheyas, Pavel Fišer, Justina Ivanauskaite, Frank Liu, Jeffrey R. Sachs   +8 more
doaj   +1 more source

DLK1-Dio3 miRNAs are highly upregulated in splenic cells from MRL-lpr lupus mice when compared to control MRL mice.

, 2016
The miRNA expression in splenocytes (A), purified splenic CD4+ T cells (B), CD19+ B cells (C), and double negative effluent fraction splenic CD4-CD19- cells (D) from MRL and MRL-lpr mice (13–16 wks old) were quantified by Taqman miRNA assays.
Rujuan Dai (80849), Ran Lu (488619), S. Ansar Ahmed (358964)   +2 more
core   +1 more source

Citrus Essential Oils in Food Safety and Health: Advances in AI‐Assisted Authentication, Antimicrobial Applications, Sustainable Extraction, and Regulatory Translation

Food Safety and Health, EarlyView.
Citrus essential oils combine sustainable extraction, AI‐assisted authentication, multi‐omics profiling, antimicrobial activity, and regulatory safety to enhance food quality, detect adulteration, and promote consumer health, and support intelligent, sustainable food systems through innovative industrial applications and circular bioeconomy strategies.
Md. Hassan Bin Nabi, Liza Akter, Yusuf Chowdhury, Mohima Akther Any, Nazmul Islam, Erni Sofia Murtini, Nurul Huda, Wahidu Zzaman   +7 more
wiley   +1 more source

MRI-based computational characterization of subcutaneous drug depots in ex vivo porcine model: implications for biotherapeutics and delivery devices

AAPS Open
Subcutaneous (SC) dosing has become an increasingly popular non-oral route of administration for biotherapeutics due to its user-friendly nature and suitability for self-administration when compared to intravenous (IV) dosing.
Shuying Wang, Mikhail D. Murashov, Michal R. Tomaszewski, Tycho Heimbach, Aparna R. Chakravarti, Corin O. Miller   +5 more
doaj   +1 more source

Splicing modulation of ATXN2 as a therapeutic strategy to regulate Ataxin-2 protein levels in ALS

Neurobiology of Disease
ATXN2 is associated with an increased risk of Amyotrophic Lateral Sclerosis (ALS), while down-regulation of ATXN2 has been shown to mitigate TDP-43 proteinopathy in ALS models.
Nicolette Heinsinger, Yi Wang, Steve Grauer, Zuo Zhang, Jacky Wong, Vladimir Simov, Marina Bukhtiyarova, Xi Ai, Craig Parish, Rebecca Meier Klein, Jason Uslaner, Sean Smith, Yuan Tian   +12 more
doaj   +1 more source