Results 51 to 60 of about 30,943 (238)
Arthritis &Rheumatology, EarlyView.Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi +9 more
wiley +1 more source
No difference in survival between knockout MRL mice and control MRL mice
, 2011 Copyright information:Taken from "Analysis of C4 and the C4 binding protein in the MRL/lpr mouse"http://arthritis-research.com/content/9/5/R114Arthritis Research & Therapy 2007;9(5):R114-R114.Published online 30 Oct 2007PMCID:PMC2212569.
Rick A Wetsel (39170) +3 more
core +1 more source
npj Vaccines, 2021 Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using immune response ...
Julie Dudášová +8 more
doaj +1 more source
IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis
Arthritis &Rheumatology, EarlyView.Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source
Taste buds of MRL/lpr mice are significantly smaller than those of MRL/+/+ mice.
, 2012 (A) H&E staining of circumvallate papillae of MRL/+/+ and MRL/lpr mice. The basal layer of the circumvallate epithelium is uneven, and taste buds are less organized in MRL/lpr mice. Scale bars, 40 µm. (B) Average areas of circumvallate taste bud profiles
Agnes Kim (169939) +9 more
core +1 more source
Communications Biology, 2021 Furse et al. use a purpose-built computational tool called Lipid Traffic Analysis to determine the spatial distribution of lipids throughout an organism.
Samuel Furse +6 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson +5 more
wiley +1 more source
, 2011 Copyright information:Taken from "Analysis of C4 and the C4 binding protein in the MRL/lpr mouse"http://arthritis-research.com/content/9/5/R114Arthritis Research & Therapy 2007;9(5):R114-R114.Published online 30 Oct 2007PMCID:PMC2212569.
Rick A Wetsel (39170) +3 more
core +1 more source
Antimicrobial Agents and ChemotherapyMK-7602 is a first-in-class dual-plasmepsin inhibitor being developed to treat malaria. Safety, tolerability, and pharmacokinetics (PK) of MK-7602 following single and multiple doses were evaluated in two phase 1 studies (7602-001; 7602-002).
Susan E. Stanley +16 more
doaj +1 more source
Biotechnology Progress, EarlyView.Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas +7 more
wiley +1 more source